M
Mei-I Chung
Researcher at Translational Genomics Research Institute
Publications - 5
Citations - 646
Mei-I Chung is an academic researcher from Translational Genomics Research Institute. The author has contributed to research in topics: Lung & Innate immune system. The author has an hindex of 4, co-authored 5 publications receiving 230 citations.
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Journal ArticleDOI
Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis
Arun C. Habermann,Austin J. Gutierrez,Linh T. Bui,Stephanie L. Yahn,Nichelle I. Winters,Carla L. Calvi,Lance M. Peter,Mei-I Chung,Chase J. Taylor,Christopher S. Jetter,Latha Raju,Jamie Roberson,Guixiao Ding,Lori Wood,Jennifer M.S. Sucre,Bradley W. Richmond,Bradley W. Richmond,Ana P. Serezani,Wyatt J. McDonnell,Simon B. Mallal,Simon B. Mallal,Matthew J. Bacchetta,James E. Loyd,Ciara M. Shaver,Lorraine B. Ware,Ross M. Bremner,Rajat Walia,Timothy S. Blackwell,Timothy S. Blackwell,Timothy S. Blackwell,Nicholas E. Banovich,Jonathan A. Kropski,Jonathan A. Kropski,Jonathan A. Kropski +33 more
TL;DR: It is reported that a remarkable shift in epithelial cell phenotypes occurs in the peripheral lung in PF and several previously unrecognized epithelialcell phenotypes are identified, including a KRT5−/KRT17+ pathologic, ECM-producing epithel cell population that was highly enriched in PF lungs.
Posted ContentDOI
Single-cell RNA-sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis
Arun C. Habermann,Austin J. Gutierrez,Linh T. Bui,Stephanie L. Yahn,Nichelle I. Winters,Carla L. Calvi,Lance M. Peter,Mei-I Chung,Chase J. Taylor,Christopher S. Jetter,Latha Raju,Jamie Roberson,Guixiao Ding,Lori Wood,Jennifer M.S. Sucre,Bradley W. Richmond,Bradley W. Richmond,Ana P. Serezani,Wyatt J. McDonnell,Simon B. Mallal,Simon B. Mallal,Matthew J. Bacchetta,James E. Loyd,Ciara M. Shaver,Lorraine B. Ware,Lorraine B. Ware,Ross M. Bremner,Rajat Walia,Timothy S. Blackwell,Timothy S. Blackwell,Timothy S. Blackwell,Nicholas E. Banovich,Jonathan A. Kropski,Jonathan A. Kropski,Jonathan A. Kropski +34 more
TL;DR: A remarkable shift in epithelial cell phenotypes occurs in the peripheral lung in PF, and several previously unrecognized epithelialcell phenotypes are identified including a KRT5−/KRT17+, pathologic ECM-producing epithel cell population that was highly enriched in PF lungs.
Journal ArticleDOI
Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity.
Linh T. Bui,Nichelle I. Winters,Mei-I Chung,Chitra Joseph,Austin J. Gutierrez,Arun C. Habermann,Taylor Adams,Jonas C. Schupp,Sergio Poli,Lance M. Peter,Chase J. Taylor,Jessica B. Blackburn,Bradley W. Richmond,Bradley W. Richmond,Andrew G. Nicholson,Doris Rassl,William A Wallace,Ivan O. Rosas,R. Gisli Jenkins,Naftali Kaminski,Jonathan A. Kropski,Jonathan A. Kropski,Jonathan A. Kropski,Nicholas E. Banovich +23 more
TL;DR: In this paper, the authors analyzed the transcriptomes of 611,398 single cells isolated from healthy and chronic lung cells to identify molecular characteristics of lung cells that may account for worse COVID-19 outcomes in patients with chronic lung diseases.
Posted ContentDOI
Single-cell RNA-sequencing reveals dysregulation of molecular programs associated with SARS-CoV-2 severity and outcomes in patients with chronic lung disease.
Linh T. Bui,Nichelle I. Winters,Mei-I Chung,Chitra Joseph,Austin J. Gutierrez,Arun C. Habermann,Taylor Adams,Jonas C. Schupp,Sergio Poli,Lance M. Peter,Chase J. Taylor,Jessica B. Blackburn,Bradley W. Richmond,Bradley W. Richmond,Andrew G. Nicholson,Doris Rassl,William A Wallace,Ivan O. Rosas,R. Gisli Jenkins,Naftali Kaminski,Jonathan A. Kropski,Jonathan A. Kropski,Jonathan A. Kropski,Nicholas E. Banovich +23 more
TL;DR: Chronic lung disease is accompanied by changes in cell-type-specific gene expression programs that prime the lung epithelium for and influence innate and adaptive immune responses to SARS-CoV-2 infection.
Posted ContentDOI
Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity.
Linh T. Bui,Nichelle I. Winters,Mei-I Chung,Chitra Joseph,Austin J. Gutierrez,Arun C. Habermann,Taylor Adams,Jonas C. Schupp,Sergio Poli,Lance M. Peter,Chase J. Taylor,Jessica B. Blackburn,Bradley W. Richmond,Bradley W. Richmond,Andrew G. Nicholson,Doris Rassl,William A Wallace,Ivan O. Rosas,R. Gisli Jenkins,Naftali Kaminski,Jonathan A. Kropski,Jonathan A. Kropski,Jonathan A. Kropski,Nicholas E. Banovich +23 more
TL;DR: This study indicates that CLD is accompanied by changes in cell-type-specific gene expression programs that prime the lung epithelium for and influence the innate and adaptive immune responses to SARS-CoV-2 infection.