Wyatt J. McDonnell

TL;DR: It is reported that a remarkable shift in epithelial cell phenotypes occurs in the peripheral lung in PF and several previously unrecognized epithelialcell phenotypes are identified, including a KRT5−/KRT17+ pathologic, ECM-producing epithel cell population that was highly enriched in PF lungs.

TL;DR: Using LIBRA-seq, a technology for high-throughput mapping of paired heavy- and light-chain BCR sequences to their cognate antigen specificities, the predicted specificities were confirmed for a number of HIV- and influenza-specific antibodies, including known and novel broadly neutralizing antibodies.

TL;DR: A remarkable shift in epithelial cell phenotypes occurs in the peripheral lung in PF, and several previously unrecognized epithelialcell phenotypes are identified including a KRT5−/KRT17+, pathologic ECM-producing epithel cell population that was highly enriched in PF lungs.

TL;DR: A fatal case of encephalitis arising during anti-programmed cell death receptor 1 therapy in a patient with metastatic melanoma is reported, and deep molecular profiling of a single case of severe anti-PD-1-induced neurotoxicity shows oligoclonal cytotoxic memory CD4+ T cells are enriched in inflamed brain tissue.

TL;DR: This analysis revealed the existence of “public” antibody clonotypes that were shared among multiple HIV-infected individuals and revealed antibodies with high sequence identity to known HIV-reactive antibodies, even in repertoires that were reported to be HIV naive.