M
Melanie Ginger
Researcher at University of Bordeaux
Publications - 13
Citations - 792
Melanie Ginger is an academic researcher from University of Bordeaux. The author has contributed to research in topics: FMR1 & Metabotropic glutamate receptor 5. The author has an hindex of 10, co-authored 13 publications receiving 664 citations. Previous affiliations of Melanie Ginger include French Institute of Health and Medical Research & Max Planck Society.
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Journal ArticleDOI
Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome
Kwang-Mook Jung,Marja D. Sepers,Marja D. Sepers,Christopher M. Henstridge,Olivier Lassalle,Olivier Lassalle,Daniela Neuhofer,Daniela Neuhofer,Henry G. S. Martin,Henry G. S. Martin,Melanie Ginger,Melanie Ginger,Andreas Frick,Andreas Frick,Nicholas V. DiPatrizio,Ken Mackie,István Katona,Daniele Piomelli,Daniele Piomelli,Olivier J. Manzoni +19 more
TL;DR: Pharmacological enhancement of 2-arachidonoyl-sn-glycerol signalling normalizes this synaptic defect and corrects behavioural abnormalities in fragile X mental retardation protein-deficient mice, which might be targeted by therapy.
Journal ArticleDOI
Dendritic channelopathies contribute to neocortical and sensory hyperexcitability in Fmr1 −/y mice
Yu Zhang,Yu Zhang,Yu Zhang,Audrey Bonnan,Audrey Bonnan,Audrey Bonnan,Guillaume Bony,Guillaume Bony,Isabelle Ferezou,Isabelle Ferezou,Susanna Pietropaolo,Susanna Pietropaolo,Melanie Ginger,Melanie Ginger,Nathalie Sans,Nathalie Sans,Jean Rossier,Jean Rossier,Ben A. Oostra,Gwen LeMasson,Gwen LeMasson,Andreas Frick,Andreas Frick +22 more
TL;DR: It is found that the primary somatosensory neocortex (S1) was hyperexcited in response to tactile sensory stimulation in Fmr1−/y mice, and the utility of BKCa channel openers for the treatment of the sensory hypersensitivity aspects of FXS is provided.
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Synaptic ionotropic glutamate receptors and plasticity are developmentally altered in the CA1 field of Fmr1 knockout mice
Yair Pilpel,Aleksander Kolleker,Sven Berberich,Melanie Ginger,Andreas Frick,Edwin Mientjes,Ben A. Oostra,Peter H. Seeburg +7 more
TL;DR: It is proposed that ionotropic glutamate receptors, as well as potentiation, are altered at a critical time point for hippocampal network development, causing long‐term changes.
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Structural-functional connectivity deficits of neocortical circuits in the Fmr1−/y mouse model of autism
Matthias G. Haberl,Matthias G. Haberl,Matthias G. Haberl,Valerio Zerbi,Andor Veltien,Melanie Ginger,Melanie Ginger,Arend Heerschap,Andreas Frick,Andreas Frick +9 more
TL;DR: FXS is identified as a “connectopathy,” providing a translational model for understanding sensory processing defects and functional decoupling of neocortical areas in FXS and ASD.
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Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice.
Elisabetta Aloisi,Elisabetta Aloisi,Katy Le Corf,Katy Le Corf,Julien P. Dupuis,Pei Zhang,Melanie Ginger,Melanie Ginger,Virginie F. Labrousse,Michela Spatuzza,Matthias G. Haberl,Matthias G. Haberl,Lara Costa,Ryuichi Shigemoto,Anke Tappe-Theodor,Fillippo Drago,Pier Vincenzo Piazza,Pier Vincenzo Piazza,Christophe Mulle,Laurent Groc,Lucia Ciranna,Maria Vincenza Catania,Andreas Frick,Andreas Frick +23 more
TL;DR: An increased lateral mobility of mGluR5 at the synaptic site in Fmr1 KO hippocampal neurons, leading to abnormal NMDAR-mediated synaptic plasticity and cognitive deficits is found.