Showing papers by "Michael Bass published in 1999"
TL;DR: Data indicate that OPGL-induced osteoclastogenesis is directly mediated through RANK on osteocLast precursor cells, and polyclonal Ab against the RANK extracellular domain promotes osteoclineogenesis in bone marrow cultures suggesting that RANK activation mediates the effects of OPGl on the osteoc last pathway.
Abstract: A receptor that mediates osteoprotegerin ligand (OPGL)-induced osteoclast differentiation and activation has been identified via genomic analysis of a primary osteoclast precursor cell cDNA library and is identical to the tumor necrosis factor receptor (TNFR) family member RANK. The RANK mRNA was highly expressed by isolated bone marrow-derived osteoclast progenitors and by mature osteoclasts in vivo. Recombinant OPGL binds specifically to RANK expressed by transfected cell lines and purified osteoclast progenitors. Transgenic mice expressing a soluble RANK-Fc fusion protein have severe osteopetrosis because of a reduction in osteoclasts, similar to OPG transgenic mice. Recombinant RANK-Fc binds with high affinity to OPGL in vitro and blocks osteoclast differentiation and activation in vitro and in vivo. Furthermore, polyclonal Ab against the RANK extracellular domain promotes osteoclastogenesis in bone marrow cultures suggesting that RANK activation mediates the effects of OPGL on the osteoclast pathway. These data indicate that OPGL-induced osteoclastogenesis is directly mediated through RANK on osteoclast precursor cells.
1,670 citations
TL;DR: The discovery of a novel secondcyclin E family member suggests that multiple unique cyclin E-CDK complexes regulate cell cycle progression, and may be rate limiting for G1 progression.
Abstract: A novel cyclin gene was discovered by searching an expressed sequence tag database with a cyclin box profile. The human cyclin E2 gene encodes a 404-amino-acid protein that is most closely related to cyclin E. Cyclin E2 associates with Cdk2 in a functional kinase complex that is inhibited by both p27Kip1 and p21Cip1. The catalytic activity associated with cyclin E2 complexes is cell cycle regulated and peaks at the G1/S transition. Overexpression of cyclin E2 in mammalian cells accelerates G1, demonstrating that cyclin E2 may be rate limiting for G1 progression. Unlike cyclin E1, which is expressed in most proliferating normal and tumor cells, cyclin E2 levels were low to undetectable in nontransformed cells and increased significantly in tumor-derived cells. The discovery of a novel second cyclin E family member suggests that multiple unique cyclin E-CDK complexes regulate cell cycle progression.
187 citations
TL;DR: In this article, the ground and excited state absorption cross sections of Cr/sup 4+/-doped yttrium aluminum garnet are reported, and their ratio is shown to weakly determine the energy output of a passively Q-switched Nd:glass laser using this material as the saturable absorber.
Abstract: Z-scan measurements of the ground and excited state absorption cross sections of Cr/sup 4+/-doped yttrium aluminum garnet are reported. These quantities are found to depend on crystal preparation but are independent of temperature from -60/spl deg/C to 98/spl deg/C. Their ratio is shown to weakly determine the energy output of a passively Q-switched Nd:glass laser using this material as the saturable absorber.
71 citations
TL;DR: In this paper, the absorption and luminescence properties of Nd3+ ions doped at 10% in this host were investigated and promising laser performance with diode laser pumping was also described.
Abstract: Studies of the spectroscopic and lasing properties of Nd3+-doped LuPO4 are reported. LuPO4 permits incorporation of lanthanide dopants in high concentration. We report the absorption and luminescence properties of Nd3+ ions doped at 10% in this host. Promising laser performance with diode laser pumping is also described.
53 citations
TL;DR: In this paper, the absorption and luminescence properties of Er3+ ions doped into single crystals of the tetragonal-symmetry host LuPO4 are reported, and the fluorescence decay of the 4 I 13/2 − 4 I 15/2 emission was found to be governed by a single exponential decay process when excited with a low-intensity pump source.
46 citations
TL;DR: In this article, the authors reported that the visible light by dyes in both liquid and polymer hosts is reported when excited by simultaneous absorption of infrared light from two different wavelength sources, by moving the intersection point of these two beams about within the volume of the dye-doped medium, one can create a true, real-time, three-dimensional display.
Abstract: Emission of visible light by dyes in both liquid and polymer hosts is reported when excited by simultaneous absorption of infrared light from two different wavelength sources. By moving the intersection point of these two beams about within the volume of the dye-doped medium, one can create a true, real-time, three-dimensional display.
29 citations
Patent•
17 Sep 1999TL;DR: In this article, the authors present methods of preparing the nucleic acid molecules and polypeptides, and methods of using these molecules for DKR polyprotein encoding, respectively.
Abstract: Disclosed are nucleic acid molecules encoding novel DKR polypeptides. Also disclosed are methods of preparing the nucleic acid molecules and polypeptides, and methods of using these molecules.
14 citations
Patent•
17 Sep 1999
TL;DR: In this article, a procedure for preparation of molecules d'acide nucleique codant for nouveaux polypeptides DKR is described. But this procedure concerne egalement des procedes de preparation of ces molecules D'acides nucleique and de ces poly peptides, ainsi que des procedures d'utilisation of these molecules.
Abstract: L'invention concerne des molecules d'acide nucleique codant pour de nouveaux polypeptides DKR. Cette invention concerne egalement des procedes de preparation de ces molecules d'acide nucleique et de ces polypeptides, ainsi que des procedes d'utilisation de ces molecules.
Patent•
28 Jan 1999TL;DR: In this paper, the nucleic acid molecules encoding cyclin E2 polypeptides and methods of using these molecules were discussed, as well as methods of preparing them and their precursors.
Abstract: Disclosed are nucleic acid molecules encoding cyclin E2 polypeptides. Also disclosed are methods of preparing the nucleic acid molecules and polypeptides, and methods of using these molecules.