T
Tiffany Y. Liang
Researcher at University of California, San Diego
Publications - 26
Citations - 6324
Tiffany Y. Liang is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Alternative splicing & Genome. The author has an hindex of 18, co-authored 26 publications receiving 5177 citations. Previous affiliations of Tiffany Y. Liang include Salk Institute for Biological Studies & San Diego State University.
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Journal ArticleDOI
Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43
Magdalini Polymenidou,Clotilde Lagier-Tourenne,Kasey R. Hutt,Stephanie C. Huelga,Jacqueline T. Moran,Tiffany Y. Liang,Shuo-Chien Ling,Eveline Sun,Edward Wancewicz,Curt Mazur,Holly B. Kordasiewicz,Yalda Sedaghat,John Paul Donohue,Lily Shiue,C. Frank Bennett,Gene W. Yeo,Don W. Cleveland +16 more
TL;DR: It is found that TDP-43 autoregulates its synthesis, in part by directly binding and enhancing splicing of an intron in the 3′ untranslated region of its own transcript, thereby triggering nonsense-mediated RNA degradation.
Journal ArticleDOI
Improved maize reference genome with single-molecule technologies
Yinping Jiao,Paul Peluso,Jinghua Shi,Tiffany Y. Liang,Michelle C. Stitzer,Bo Wang,Michael S. Campbell,Joshua C. Stein,Xuehong Wei,Chen-Shan Chin,Katherine E. Guill,Michael Regulski,Sunita Kumari,Andrew Olson,Jonathan I. Gent,Kevin L. Schneider,Thomas K. Wolfgruber,Michael R. May,Nathan M. Springer,Eric Antoniou,W. Richard McCombie,Gernot G. Presting,Michael D. McMullen,Jeffrey Ross-Ibarra,R. Kelly Dawe,Alex Hastie,David R. Rank,Doreen Ware,Doreen Ware +28 more
TL;DR: The assembly and annotation of a reference genome of maize is reported, using single-molecule real-time sequencing and high-resolution optical mapping to identify transposable element lineage expansions that are unique to maize.
Journal ArticleDOI
Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs
Clotilde Lagier-Tourenne,Magdalini Polymenidou,Kasey R. Hutt,Anthony Q. Vu,Michael Baughn,Stephanie C. Huelga,Kevin M. Clutario,Shuo-Chien Ling,Tiffany Y. Liang,Curt Mazur,Edward Wancewicz,Aneeza Kim,Andrew T. Watt,Sue Freier,Geoffrey G. Hicks,John Paul Donohue,Lily Shiue,C. Frank Bennett,John Ravits,Don W. Cleveland,Gene W. Yeo,Gene W. Yeo +21 more
TL;DR: Depletion of FUS/TLS from the adult nervous system altered the levels or splicing of >950 mRNAs, most of which are distinct from RNAs dependent on TDP-43, supporting a common loss-of-function pathway as one component underlying motor neuron death from misregulation of T DP-43 or FUS-43.
Journal ArticleDOI
Extensive sequencing of seven human genomes to characterize benchmark reference materials
Justin M. Zook,David Catoe,Jennifer McDaniel,Lindsay K. Vang,Noah Spies,Noah Spies,Arend Sidow,Ziming Weng,Yuling Liu,Christopher E. Mason,Noah Alexander,Elizabeth Henaff,Alexa B. R. McIntyre,Dhruva Chandramohan,Feng Chen,Erich Jaeger,Ali Moshrefi,Khoa Pham,William Stedman,Tiffany Y. Liang,Michael Saghbini,Zeljko Dzakula,Alex Hastie,Han Cao,Gintaras Deikus,Eric E. Schadt,Robert Sebra,Ali Bashir,R Truty,Christopher C. Chang,Natali Gulbahce,Keyan Zhao,Srinka Ghosh,Fiona Hyland,Yutao Fu,Mark Chaisson,Chunlin Xiao,Jonathan Trow,Stephen T. Sherry,Alexander Wait Zaranek,Madeleine Ball,Jason Bobe,Preston W. Estep,George M. Church,Patrick Marks,Sofia Kyriazopoulou-Panagiotopoulou,Grace X.Y. Zheng,Michael Schnall-Levin,Heather Ordonez,Patrice A Mudivarti,Kristina Giorda,Ying Sheng,Karoline Bjarnesdatter Rypdal,Marc L. Salit,Marc L. Salit +54 more
TL;DR: A large, diverse set of sequencing data for seven human genomes is described; five are current or candidate NIST Reference Materials and two Personal Genome Project trios, one of Ashkenazim Jewish ancestry and one of Chinese ancestry are described.
Journal ArticleDOI
An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells
Gene W. Yeo,Nicole G. Coufal,Tiffany Y. Liang,Tiffany Y. Liang,Grace E. Peng,Xiang-Dong Fu,Fred H. Gage +6 more
TL;DR: This work decoded functional RNA elements in vivo by constructing an RNA map for the cell type–specific splicing regulator FOX2 via cross-linking immunoprecipitation coupled with high-throughput sequencing in human embryonic stem cells and suggested that FOX2 functions as a critical regulator of a splicing network.