K
Kelly E. Seaton
Researcher at Duke University
Publications - 58
Citations - 2500
Kelly E. Seaton is an academic researcher from Duke University. The author has contributed to research in topics: Antibody & Vaccination. The author has an hindex of 20, co-authored 48 publications receiving 1922 citations. Previous affiliations of Kelly E. Seaton include Pennsylvania State University & Durham University.
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Journal ArticleDOI
Vaccine-induced Env V1-V2 IgG3 correlates with lower HIV-1 infection risk and declines soon after vaccination
Nicole L. Yates,Nicole L. Yates,Hua-Xin Liao,Hua-Xin Liao,Youyi Fong,Allan C. deCamp,Nathan Vandergrift,Nathan Vandergrift,William T. Williams,William T. Williams,S. Munir Alam,S. Munir Alam,Guido Ferrari,Guido Ferrari,Zhi Yong Yang,Kelly E. Seaton,Kelly E. Seaton,Phillip W. Berman,Michael D. Alpert,David T. Evans,Robert J. O'Connell,Donald P. Francis,Faruk Sinangil,Carter Lee,Sorachai Nitayaphan,Supachai Rerks-Ngarm,Jaranit Kaewkungwal,Punnee Pitisuttithum,James Tartaglia,Abraham Pinter,Susan Zolla-Pazner,Peter B. Gilbert,Gary J. Nabel,Nelson L. Michael,Jerome H. Kim,David C. Montefiori,David C. Montefiori,Barton F. Haynes,Barton F. Haynes,Georgia D. Tomaras +39 more
TL;DR: HIV-1–specific IgG3 responses were not long-lived, which was consistent with the waning efficacy of the RV144 vaccine, and should be evaluated in future HIV-1 vaccine efficacy trials to further refine immune correlates of protection.
Journal ArticleDOI
Combination therapy with anti-HIV-1 antibodies maintains viral suppression
Pilar Mendoza,Henning Gruell,Lilian Nogueira,Joy A. Pai,Allison L. Butler,Katrina G. Millard,Clara Lehmann,Isabelle Suárez,Thiago Y. Oliveira,Julio C. C. Lorenzi,Yehuda Z. Cohen,Christoph Wyen,Christoph Wyen,Tim Kümmerle,Tim Kümmerle,Theodora K. Karagounis,Ching-Lan Lu,Lisa Handl,Cecilia Unson-O’Brien,Roshni Patel,Carola Ruping,Maike Schlotz,Maggi Witmer-Pack,Irina Shimeliovich,Gisela Kremer,Eleonore Thomas,Kelly E. Seaton,Jill Horowitz,Anthony P. West,Pamela J. Bjorkman,Georgia D. Tomaras,Roy M. Gulick,Nico Pfeifer,Gerd Fätkenheuer,Michael S. Seaman,Florian Klein,Marina Caskey,Michel C. Nussenzweig,Michel C. Nussenzweig +38 more
TL;DR: It is concluded that the combination of the anti-HIV-1 monoclonal antibodies 3BNC117 and 10-1074 can maintain long-term suppression in the absence of antiretroviral therapy in individuals with antibody-sensitive viral reservoirs.
Journal ArticleDOI
Safety and antiviral activity of combination HIV-1 broadly neutralizing antibodies in viremic individuals.
Yotam Bar-On,Henning Gruell,Till Schoofs,Joy A. Pai,Lilian Nogueira,Allison L. Butler,Katrina G. Millard,Clara Lehmann,Isabelle Suárez,Thiago Y. Oliveira,Theodora K. Karagounis,Yehuda Z. Cohen,Christoph Wyen,Christoph Wyen,Stefan Scholten,Lisa Handl,Shiraz A. Belblidia,Juan Dizon,Jörg Janne Vehreschild,Maggi Witmer-Pack,Irina Shimeliovich,Kanika Jain,Kerstin Fiddike,Kelly E. Seaton,Nicole L. Yates,Jill Horowitz,Roy M. Gulick,Nico Pfeifer,Georgia D. Tomaras,Michael S. Seaman,Gerd Fätkenheuer,Marina Caskey,Florian Klein,Michel C. Nussenzweig,Michel C. Nussenzweig +34 more
TL;DR: Combination of two broadly neutralizing antibodies is effective in reducing HIV-1 viremia and in limiting the emergence of resistant viral variants in individuals harboring antibody-sensitive viruses.
Journal ArticleDOI
Diversion of HIV-1 vaccine–induced immunity by gp41-microbiota cross-reactive antibodies
Wilton B. Williams,Hua-Xin Liao,M. Anthony Moody,Thomas B. Kepler,S. Munir Alam,Feng Gao,Kevin Wiehe,Ashley M. Trama,Kathryn J. Jones,Ruijun Zhang,Hongshuo Song,Dawn J. Marshall,John F. Whitesides,Kaitlin Sawatzki,Axin Hua,Pinghuang Liu,Matthew Zirui Tay,Kelly E. Seaton,Xiaoying Shen,Andrew Foulger,Krissey E. Lloyd,Robert Parks,Justin Pollara,Guido Ferrari,Jae-Sung Yu,Nathan Vandergrift,David C. Montefiori,Magdalena E. Sobieszczyk,Scott M. Hammer,Shelly Karuna,Peter B. Gilbert,Doug Grove,Nicole Grunenberg,M. Juliana McElrath,John R. Mascola,Richard A. Koup,Lawrence Corey,Gary J. Nabel,Cecilia Morgan,Gavin J. Churchyard,Janine Maenza,Michael C. Keefer,Barney S. Graham,Lindsey R. Baden,Georgia D. Tomaras,Barton F. Haynes +45 more
TL;DR: The hypothesis that neonatal immunization with HIV-1 envelope may be able to imprint the B cell repertoire to respond to envelope antigenic sites that may otherwise be subdominant or disfavored is raised.
Journal ArticleDOI
Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV
Mario Roederer,Brandon F. Keele,Stephen D. Schmidt,Rosemarie D. Mason,Hugh C. Welles,Hugh C. Welles,Will Fischer,Celia C. LaBranche,Kathryn E. Foulds,Mark K. Louder,Zhi-Yong Yang,Zhi-Yong Yang,John Paul Todd,Adam P. Buzby,Linh Mach,Ling Shen,Kelly E. Seaton,Brandy M. Ward,Robert T. Bailer,Raphael Gottardo,Wenjuan Gu,Guido Ferrari,S. Munir Alam,Thomas N. Denny,David C. Montefiori,Georgia D. Tomaras,Bette T. Korber,Martha Nason,Robert A. Seder,Richard A. Koup,Norman L. Letvin,Srinivas S. Rao,Gary J. Nabel,Gary J. Nabel,John R. Mascola +34 more
TL;DR: A nonhuman primate challenge model with simian immunodeficiency virus (SIV) shows that antibodies to the SIV envelope are necessary and sufficient to prevent infection, and identifies a two-amino-acid signature that alters antigenicity and confers neutralization resistance.