Michael D. Radmacher

TL;DR: Many genes underlying the classification of this subset of melanomas are differentially regulated in invasive melanomas that form primitive tubular networks in vitro, a feature of some highly aggressive metastatic melanomas.

TL;DR: Significantly different groups of genes are expressed by breast cancers with BRCA1 mutations and breast cancersWith BRCa2 mutations, the results suggest that a heritable mutation influences the gene-expression profile of the cancer.

TL;DR: In this article, the authors address statistical issues that arise from the use of DNA microarrays for an important group of objectives that has been called "class prediction", which includes derivation of predictors of prognosis, response to therapy, or any phenotype or genotype defined independently of the gene expression profile.

TL;DR: Statistical issues that arise from the use of DNA microarrays for an important group of objectives that has been called “class prediction” are addressed, which includes derivation of predictors of prognosis, response to therapy, or any phenotype or genotype defined independently of the gene expression profile.

TL;DR: The R172 IDH2 mutations, previously unreported in AML, characterize a novel subset of CN-AML patients lacking other prognostic mutations and associate with unique gene- and microRNA-expression profiles that may lead to the discovery of novel, therapeutically targetable leukemogenic mechanisms.