M
Michael F. Hirshman
Researcher at Harvard University
Publications - 143
Citations - 22282
Michael F. Hirshman is an academic researcher from Harvard University. The author has contributed to research in topics: Skeletal muscle & Glucose uptake. The author has an hindex of 65, co-authored 131 publications receiving 20279 citations. Previous affiliations of Michael F. Hirshman include Merck & Co. & Joslin Diabetes Center.
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Journal ArticleDOI
Epinephrine and insulin stimulate different mitogen-activated protein kinase signaling pathways in rat skeletal muscle
Raffaele Napoli,Lindsay Gibson,Michael F. Hirshman,Marni D. Boppart,Scott D. Dufresne,Edward S. Horton,Laurie J. Goodyear +6 more
TL;DR: These data are the first to demonstrate that epinephrine can increase JNK activity, which may be one of the underlying molecular mechanisms through which these hormones regulate opposing metabolic functions.
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Maternal and paternal exercise regulate offspring metabolic health and beta cell phenotype.
Jia Zheng,Ana Barbara Alves-Wagner,Kristin I. Stanford,Noah B. Prince,Kawai So,Joram D Mul,Ercument Dirice,Michael F. Hirshman,Rohit N. Kulkarni,Laurie J. Goodyear +9 more
TL;DR: Maternal and paternal exercise have additive effects to improve glucose tolerance in offspring as they age, accompanied by changes in the offspring endocrine pancreas, with important implications for the prevention and treatment of type 2 diabetes.
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Exercise training increases GLUT-4 protein in rat adipose cells
TL;DR: The total amount of GLUT-4 protein, but notGLUT-1, is increased in adipose cells by exercise training and that this increase is due primarily to an increase in intracellular GLut-4.
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Islet transplantation under the kidney capsule fully corrects the impaired skeletal muscle glucose transport system of streptozocin diabetic rats.
Raffaele Napoli,Alberto M. Davalli,Michael F. Hirshman,Raimund Weitgasser,Gordon C. Weir,Edward S. Horton +5 more
TL;DR: An adequate insulin delivery in the peripheral circulation, obtained by islet transplantation, fully restores the muscle glucose transport system to normal in streptozocin diabetic rats.
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Exercise training increases the number of glucose transporters in rat adipose cells.
Michael F. Hirshman,L. J. Wardzala,Laurie J. Goodyear,S. P. Fuller,E. D. Horton,Edward S. Horton +5 more
TL;DR: It is demonstrated that the increased glucose transport and metabolism observed in insulin-stimulated adipose cells from exercise-trained rats is due, primarily, to an increase in the number of plasma membrane glucose transporters translocated from an enlarged intracellular pool.