M
Michael F. Hirshman
Researcher at Harvard University
Publications - 143
Citations - 22282
Michael F. Hirshman is an academic researcher from Harvard University. The author has contributed to research in topics: Skeletal muscle & Glucose uptake. The author has an hindex of 65, co-authored 131 publications receiving 20279 citations. Previous affiliations of Michael F. Hirshman include Merck & Co. & Joslin Diabetes Center.
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Journal ArticleDOI
Acute exercise increases the number of plasma membrane glucose transporters in rat skeletal muscle.
Michael F. Hirshman,Harriet Wallberg-Henriksson,L. J. Wardzala,E. D. Horton,Edward S. Horton +4 more
TL;DR: There was a 2‐fold increase in cytochalasin B binding sites, measured in purified plasma membranes enriched 30‐fold in 5′‐nucleotidase activity, which may explain in part, the increase in glucose transport rate which persists in skeletal muscle following exercise.
Journal ArticleDOI
MicroRNA-455 regulates brown adipogenesis via a novel HIF1an-AMPK-PGC1α signaling network.
Hongbin Zhang,Hongbin Zhang,Meiping Guan,Kristy L. Townsend,Tian Lian Huang,Ding An,Xu Yan,Ruidan Xue,Tim J. Schulz,Jonathon N. Winnay,Marcelo A. Mori,Michael F. Hirshman,Karsten Kristiansen,John S. Tsang,Andrew P. White,Aaron M. Cypess,Laurie J. Goodyear,Yu-Hua Tseng +17 more
TL;DR: The data reveal a novel microRNA‐regulated signaling network that controls brown adipogenesis and may be a potential therapeutic target for human metabolic disorders.
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The Muscle-specific Protein Phosphatase PP1G/RGL(GM) Is Essential for Activation of Glycogen Synthase by Exercise
William G. Aschenbach,Yoichi Suzuki,Kristine Breeden,Clara Prats,Michael F. Hirshman,Scott D. Dufresne,Kei Sakamoto,Pier Giuseppe Vilardo,Marcella Steele,Jong-Hwa Kim,Shao-liang Jing,Laurie J. Goodyear,Anna A. DePaoli-Roach +12 more
TL;DR: Although PP1G/RGL is not necessary for activation of GS by insulin, it is essential for regulation of glycogen metabolism under basal conditions and in response to contractile activity, and may explain the reduced muscle glycogen content in the RGL KO mice, despite the normal insulinactivation of GS.
Journal ArticleDOI
Effect of AICAR Treatment on Glycogen Metabolism in Skeletal Muscle
William G. Aschenbach,Michael F. Hirshman,Nobuharu L. Fujii,Kei Sakamoto,Kirsten F. Howlett,Laurie J. Goodyear +5 more
TL;DR: AICAR treatment does not promote glycogen accumulation in skeletal muscle in vivo by altering glycogen synthase and glycogen phosphorylase, and the increased glycogen is due to the well-known effects of AICAR to increase glucose uptake.
Journal ArticleDOI
Differential Role of Insulin/IGF-1 Receptor Signaling in Muscle Growth and Glucose Homeostasis.
Brian T. O’Neill,Hans P.M.M. Lauritzen,Michael F. Hirshman,Graham Smyth,Laurie J. Goodyear,C. Ronald Kahn +5 more
TL;DR: Loss of insulin/IGF-1 signaling impairs muscle growth, but not whole-body glucose tolerance due to increased membrane localization of glucose transporters, indicating that interactions between these receptors and other proteins in muscle can impair glucose homeostasis.