Michael F. Hirshman

TL;DR: The results suggest that the AS160 CBD directly regulates contraction-induced glucose uptake in mouse muscle and that calmodulin provides an additional means of modulating AS160 Rab-GAP function independent of phosphorylation.

TL;DR: Exercise and weight loss are cornerstones in the treatment and prevention of type 2 diabetes, and both interventions function to increase insulin sensitivity and glucose uptake into skeletal muscle, but surprisingly, there was no effect on expression or phosphorylation of any of the muscle-signaling proteins.

TL;DR: It is demonstrated that oral ingestion of glucose increases the rate of glucose transport across the plasma membrane and causes GLUT4 translocation in human skeletal muscle, which suggests that under physiological conditions the translocation ofGLUT4 is an important mechanism for the stimulation of glucose uptake inhuman skeletal muscle.

TL;DR: In this article, the authors used confocal imaging to visualize endogenous interleukin 6 (IL-6) protein in fixed muscle fibers and found IL-6 in small vesicle structures distributed throughout the fibers under basal conditions.

TL;DR: A critical role is established for LKB1 for normal cardiac function under both aerobic conditions and during recovery after ischemia in mice generated using the Cre-Lox system.