M
Michael F. Hirshman
Researcher at Harvard University
Publications - 143
Citations - 22282
Michael F. Hirshman is an academic researcher from Harvard University. The author has contributed to research in topics: Skeletal muscle & Glucose uptake. The author has an hindex of 65, co-authored 131 publications receiving 20279 citations. Previous affiliations of Michael F. Hirshman include Merck & Co. & Joslin Diabetes Center.
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Journal ArticleDOI
AS160 regulates insulin- and contraction-stimulated glucose uptake in mouse skeletal muscle.
Henning F. Kramer,Carol A. Witczak,Eric B. Taylor,Nobuharu L. Fujii,Michael F. Hirshman,Laurie J. Goodyear,Laurie J. Goodyear +6 more
TL;DR: The data suggest that AS160 regulates both insulin- and contraction-stimulated glucose metabolism in mouse skeletal muscle in vivo and that the effects of mutant AS160 on the actions of insulin and contraction are not identical.
Journal ArticleDOI
The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue
Matthew D. Lynes,Luiz O. Leiria,Morten Lundh,Morten Lundh,Alexander Bartelt,Farnaz Shamsi,Tian Lian Huang,Hirokazu Takahashi,Michael F. Hirshman,Christian Schlein,Alexandra Lee,Lisa A. Baer,Francis J. May,Fei Gao,Niven R. Narain,Emily Y. Chen,Michael A. Kiebish,Aaron M. Cypess,Matthias Blüher,Laurie J. Goodyear,Gökhan S. Hotamisligil,Kristin I. Stanford,Yu-Hua Tseng +22 more
TL;DR: It is shown that the lipid 12, 13-dihydroxy-9Z-octadecenoic acid (12,13-diHOME) is a stimulator of BAT activity, and that its levels are negatively correlated with body-mass index and insulin sensitivity, and this data suggest that 12,13 -diHOME, or a functional analog, could be developed as a treatment for metabolic disorders.
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Nitric oxide increases glucose uptake through a mechanism that is distinct from the insulin and contraction pathways in rat skeletal muscle.
TL;DR: No stimulates glucose uptake through a mechanism that is distinct from both the insulin and contraction signaling pathways, suggesting that NO is a critical mediator of insulin- and/or contraction-stimulated transport.
Journal ArticleDOI
Reduced expression of the murine p85α subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes
Franck Mauvais-Jarvis,Kohjiro Ueki,David A. Fruman,Michael F. Hirshman,Kei Sakamoto,Laurie J. Goodyear,Matteo Iannacone,Domenico Accili,Lewis C. Cantley,C. Ronald Kahn +9 more
TL;DR: Despite the decrease in p85alpha, PI 3-kinase activation is normal, insulin-stimulated Akt activity is increased, and glucose tolerance and insulin sensitivity are improved, and data suggest that regulation of p85 alpha levels may provide a novel therapeutic target for the treatment of type 2 diabetes.
Journal ArticleDOI
A Novel Role for Subcutaneous Adipose Tissue in Exercise-Induced Improvements in Glucose Homeostasis
Kristin I. Stanford,Roeland J.W. Middelbeek,Roeland J.W. Middelbeek,Kristy L. Townsend,Kristy L. Townsend,Min-Young Lee,Min-Young Lee,Hirokazu Takahashi,Hirokazu Takahashi,Kawai So,Kristen M. Hitchcox,Kathleen R. Markan,Katharina Hellbach,Michael F. Hirshman,Yu-Hua Tseng,Yu-Hua Tseng,Laurie J. Goodyear,Laurie J. Goodyear +17 more
TL;DR: Exercise training causes adaptations to scWAT that elicit metabolic improvements in other tissues, demonstrating a previously unrecognized role for adipose tissue in the beneficial effects of exercise on systemic glucose homeostasis.