Michael F. Hirshman

TL;DR: The findings suggest that TRB3 regulates muscle fiber type via a peroxisome proliferator-activated receptor-α (PPAR-α)-regulated miR499/miR208b pathway, revealing a novel function for TRB 3 in the regulation of skeletal muscle fibertype and exercise capacity.

TL;DR: In this article, the p38 mitogen-activated protein kinase (MAPK) has been proposed to be a downstream intermediate of AMPK-mediated signaling in skeletal muscle, but it was shown that p38 MAPK is not a downstream component of AMP-mediated signalling.

TL;DR: Akt2-dependent NH₂-terminal dephosphorylation may be the site for "fine-tuning" insulin-mediated GS activation in humans, according to a study population of nondiabetic twins.

TL;DR: Islet transplantation fully corrected the diabetes-induced changes in protein tyrosine phosphorylation and PI 3-kinase activity and normalized IRS-1 and IRS-2 protein content in both skeletal muscle and myocardium, suggesting that insulin delivered into the systemic circulation by pancreatic islets transplanted under the kidney capsule can adequately correct altered insulin signaling mechanisms in insulinopenic diabetes.

TL;DR: High-dose hGH treatment for 4 weeks did not alter post-prandial skeletal muscle glucose transport activity and mRNA data suggest that this reduction might result from a decrease in the synthesis of GLUT1.