Michael Flossdorf

TL;DR: A mouse model allowing inducible genetic labelling of the most primitive Tie2+ HSCs in bone marrow is devised, and label progression along haematopoietic development is quantified by limiting dilution analysis and data-driven modelling, which uncovers fundamental differences between the normal maintenance of the haematography system, its regulation by challenge, and its re-establishment after transplantation.

TL;DR: By means of in vivo fate mapping, a striking variability of immune responses derived from individual CD8+ T cells is found and it is shown that robust acute and recall immunity requires the initial recruitment of multiple precursors.

TL;DR: A central role for miR-182 is demonstrated in the physiological regulation of IL-2-driven helper T cell–mediated immune responses and new therapeutic possibilities are opened.

TL;DR: Observations establish that adult tissue stem cells reside within the CD62L(+) Tcm cell compartment and highlight the promising therapeutic potential of this immune cell subset.

TL;DR: The present findings explain how IL-2 can play two disctinct roles in immune regulation and point to a hitherto largely unexplored spatiotemporal complexity of cytokine signaling.