M
Michael G. Montague
Researcher at J. Craig Venter Institute
Publications - 12
Citations - 3012
Michael G. Montague is an academic researcher from J. Craig Venter Institute. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 10, co-authored 12 publications receiving 2691 citations. Previous affiliations of Michael G. Montague include Chestnut Hill College.
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Journal ArticleDOI
Creation of a Bacterial Cell Controlled by a Chemically Synthesized Genome
Daniel G. Gibson,John I. Glass,Carole Lartigue,Vladimir N. Noskov,Ray-Yuan Chuang,Mikkel A. Algire,Gwynedd A. Benders,Michael G. Montague,Li Ma,Monzia Moodie,Chuck Merryman,Sanjay Vashee,Radha Krishnakumar,Nacyra Assad-Garcia,Cynthia Andrews-Pfannkoch,Evgeniya A. Denisova,Lei Young,Zhi-Qing Qi,Thomas H. Segall-Shapiro,Christopher H. Calvey,Prashanth P. Parmar,Clyde A. Hutchison,Hamilton O. Smith,J. Craig Venter +23 more
TL;DR: The design, synthesis, and assembly of the 1.08–mega–base pair Mycoplasma mycoides JCVI-syn1.0 genome starting from digitized genome sequence information and its transplantation into a M. capricolum recipient cell to create new cells that are controlled only by the synthetic chromosome are reported.
Journal ArticleDOI
One-step assembly in yeast of 25 overlapping DNA fragments to form a complete synthetic Mycoplasma genitalium genome
Daniel G. Gibson,Gwynedd A. Benders,Kevin C. Axelrod,Jayshree Zaveri,Mikkel A. Algire,Monzia Moodie,Michael G. Montague,J. Craig Venter,Hamilton O. Smith,Clyde A. Hutchison +9 more
TL;DR: Assembly of the synthetic genome from 25 overlapping fragments in a single step using yeast recombination greatly simplifies the assembly of large DNA molecules from both synthetic and natural fragments.
Journal ArticleDOI
Grand challenges in space synthetic biology.
TL;DR: The challenges and opportunities that lie ahead in the field of space synthetic biology are identified, while relevant progress is highlighted, to outline anticipated broader benefits from this field, because space engineering advances will drive technological innovation on Earth.
Journal ArticleDOI
Genome-wide engineering of an infectious clone of herpes simplex virus type 1 using synthetic genomics assembly methods.
Lauren M. Oldfield,Peter Grzesik,Alexander A. Voorhies,Nina Alperovich,Derek MacMath,Claudia D. Najera,Diya Sabrina Chandra,Sanjana Prasad,Vladimir N. Noskov,Michael G. Montague,Robert Friedman,Prashant Desai,Sanjay Vashee +12 more
TL;DR: An application of synthetic genomics assembly tools that enables rapid and efficient generation of combinatorial mutations in herpesvirus genomes is described, which can help understand basic virus biology, facilitate vaccine development, and aid development of next-generation virus-based delivery systems.
Journal ArticleDOI
Sequence analysis of a complete 1.66 Mb Prochlorococcus marinus MED4 genome cloned in yeast.
Christian Tagwerker,Christopher L. Dupont,Bogumil J. Karas,Li Ma,Ray-Yuan Chuang,Gwynedd A. Benders,Adi Ramon,Mark Novotny,Michael G. Montague,Pratap Venepally,Daniel Brami,Ariel S. Schwartz,Cynthia Andrews-Pfannkoch,Daniel G. Gibson,John I. Glass,Hamilton O. Smith,J. Craig Venter,Clyde A. Hutchison +17 more
TL;DR: Evidence of transformation, replication and maintenance of this 1.66 Mb intact bacterial genome in S. cerevisiae is provided.