M
Michael Lidschreiber
Researcher at Max Planck Society
Publications - 28
Citations - 1642
Michael Lidschreiber is an academic researcher from Max Planck Society. The author has contributed to research in topics: RNA polymerase II & Transcription (biology). The author has an hindex of 15, co-authored 28 publications receiving 1397 citations. Previous affiliations of Michael Lidschreiber include Center for Integrated Protein Science Munich & Science for Life Laboratory.
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Journal ArticleDOI
Uniform transitions of the general RNA polymerase II transcription complex.
Andreas Mayer,Michael Lidschreiber,Matthias Siebert,Kristin Leike,Johannes Söding,Patrick Cramer +5 more
TL;DR: In this article, the authors present genome-wide occupancy profiles for RNA polymerase (Pol) II, its phosphorylated forms and transcription factors in proliferating yeast, showing that the resulting elongation complex is composed of all the elongation factors and shows high levels of Ser7 and Ser5 phosphorylation on the C-terminal repeat domain (CTD) of Pol II.
Journal ArticleDOI
CTD tyrosine phosphorylation impairs termination factor recruitment to RNA polymerase II.
Andreas Mayer,Martin Heidemann,Michael Lidschreiber,Amelie Schreieck,Mai Sun,Corinna Hintermair,Elisabeth Kremmer,Dirk Eick,Patrick Cramer +8 more
TL;DR: Results show that CTD modifications trigger and block factor recruitment and lead to an extended CTD code that explains transcription cycle coordination on the basis of differential phosphorylation of Tyr1, Ser2, and Ser5.
Journal ArticleDOI
Molecular Basis for Coordinating Transcription Termination with Noncoding RNA Degradation
Agnieszka Tudek,Odil Porrua,Tomasz Kabzinski,Tomasz Kabzinski,Michael Lidschreiber,Karel Kubíček,Karel Kubíček,Andrea Fortova,Andrea Fortova,François Lacroute,Stepanka Vanacova,Stepanka Vanacova,Patrick Cramer,Richard Štefl,Richard Štefl,Domenico Libri +15 more
TL;DR: In this paper, structural and functional evidence was provided that the same domain of Nrd1p interacts with RNA polymerase II and Trf4p in a mutually exclusive manner, thus defining two alternative forms of the NNS complex, one involved in termination and the other in degradation.
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Genome-wide Analysis of RNA Polymerase II Termination at Protein-Coding Genes
Carlo Baejen,Jessica Andreani,Phillipp Torkler,Sofia Battaglia,Bjoern Schwalb,Michael Lidschreiber,Kerstin C. Maier,Andrea Boltendahl,Petra Rus,Stephanie Esslinger,Johannes Söding,Patrick Cramer +11 more
TL;DR: It is found that the 3'-transition globally requires the Pol II elongation factor Spt5 and factors involved in the recognition of the polyadenylation (pA) site and in endonucleolytic RNA cleavage.
Journal ArticleDOI
NASC-seq monitors RNA synthesis in single cells.
Gert-Jan Hendriks,Lisa A. Jung,Anton J. M. Larsson,Michael Lidschreiber,Michael Lidschreiber,Oscar Andersson Forsman,Katja Lidschreiber,Patrick Cramer,Patrick Cramer,Rickard Sandberg +9 more
TL;DR: New transcriptome alkylation-dependent single-cell RNA sequencing (NASC-seq) is developed, to monitor newly synthesised and pre-existing RNA simultaneously in single cells, and enables precise temporal monitoring of RNA synthesis at single- cell resolution during homoeostasis, perturbation responses and cellular differentiation.