Michael Sachse

TL;DR: Using exome sequencing, it is shown that analysis of rare coding variation in 3,871 autism cases and 9,937 ancestry-matched or parental controls implicates 22 autosomal genes at a false discovery rate of < 0.05, plus a set of 107 genes strongly enriched for those likely to affect risk (FDR < 0.30).

TL;DR: Data on comorbidity rates and symptom overlap is presented and common and disorder-specific risk factors are discussed, including recent proteomic studies, and neuropsychological findings in the areas of attention, reward processing, and social cognition are compared between both disorders.

TL;DR: Results of this study are in line with previous studies reporting only minimal EF difficulties in older individuals with ASD when assessed by computerized tasks, but the finding of impaired visuo-motor information processing should be accounted for in further neuropsychological studies in ASD.

TL;DR: Functional analyses revealed that minor alleles predicted to alter splicing factor binding sites significantly increase levels of an alternative mRNA isoform of the respective gene while keeping the overall expression of the gene constant, underpin the role of ASD candidate genes in postsynaptic FMRP regulation.

TL;DR: Short-term ASD-specific add-on group-based psychotherapy has shown postintervention efficacy with regard to parent-rated social responsiveness predominantly in male high-functioning children and adolescents with ASD, and future studies should implement blinded standardized observational measures of peer-related social interaction.