M
Michel Bouvier
Researcher at Université de Montréal
Publications - 412
Citations - 33931
Michel Bouvier is an academic researcher from Université de Montréal. The author has contributed to research in topics: Receptor & G protein-coupled receptor. The author has an hindex of 97, co-authored 396 publications receiving 31267 citations. Previous affiliations of Michel Bouvier include École Polytechnique de Montréal & University of Catania.
Papers
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Journal ArticleDOI
Common coupling map advances GPCR-G protein selectivity
Alexander S. Hauser,Charlotte Avet,Claire Normand,Arturo Mancini,Asuka Inoue,Michel Bouvier,David E. Gloriam +6 more
TL;DR: A common coupling map uncovering novel couplings supported by both large-scale studies, the selectivity/promiscuity of GPCRs and G proteins, and how the co-coupling and co-expression of G proteins compare to the families from phylogenetic relationships is reported.
Journal ArticleDOI
Bioluminescence resonance energy transfer-based biosensors allow monitoring of ligand- and transducer-mediated GPCR conformational changes.
Louis-Philippe Picard,Anne Marie Schönegge,Anne Marie Schönegge,Martin J. Lohse,Martin J. Lohse,Michel Bouvier +5 more
TL;DR: New bioluminescent resonance energy transfer-based biosensors that can probe the conformational rearrangement promoted by ligands with different signaling efficacies as well as the impact of transducers such as G proteins and β-arrestin on these conformational transitions are described.
Journal ArticleDOI
Structure-based discovery of nonopioid analgesics acting through the α2A-adrenergic receptor
Elissa A Fink,Jun Xu,Harald Hübner,Joao M. Braz,Philipp Seemann,Charlotte Avet,Veronica B. Craik,Dorothee Weikert,Maximilian F. Schmidt,Chase M Webb,Nataliya A. Tolmachova,Yurii S. Moroz,Xi-Ping Huang,Chakrapani Kalyanaraman,Stefan Gahbauer,Geng Chen,Zheng Liu,Matthew P. Jacobson,John J. Irwin,Michel Bouvier,Yang Du,Brian K. Shoichet,Allan I. Basbaum,P. Gmeiner +23 more
TL;DR: Several compounds, including the initial docking hit '9087, exerted on-target analgesic activity in multiple in vivo pain models without sedation and are interesting as therapeutic leads that lack the liabilities of opioids and the sedation of dexmedetomidine.
KCTD Hetero-oligomers confer unique kinetic properties on Hippocampal GABA B Receptor-Induced K + Currents
T. Fritzius,R. Turecek,R. Seddik,Hiroyuki Kobayashi,J. Tiao,P.D. Rem,M. Metz,M. Kralikova,Michel Bouvier,M. Gassmann,B. Bettler +10 more
TL;DR: The data demonstrate that simultaneous assembly of distinct KCTDs at the receptor increases the molecular and functional repertoire of native GABAB receptors and modulates physiologically induced K+ current responses in the hippocampus.
Patent
Compound screening based on a window of chemical-messenger-independent activity
TL;DR: In this article, a method of testing chemical compounds for their ability to inhibit chemical-messenger-independent activity of G protein-coupled receptors involving expressing DNA encoding a G protein coupled receptor in a cell expression system was presented.