M
Michel Bouvier
Researcher at Université de Montréal
Publications - 412
Citations - 33931
Michel Bouvier is an academic researcher from Université de Montréal. The author has contributed to research in topics: Receptor & G protein-coupled receptor. The author has an hindex of 97, co-authored 396 publications receiving 31267 citations. Previous affiliations of Michel Bouvier include École Polytechnique de Montréal & University of Catania.
Papers
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Patent
Methods of screening compounds for their pharmacological relevance based on downregulation of recombinant receptors
TL;DR: In this paper, a method for determining the ability of compounds to act as antagonists by observing their ability to downregulate recombinant G-protein coupled receptors in membrane preparations is described.
Posted ContentDOI
Development of conformational BRET biosensors that monitor Ezrin, Radixin and Moesin activation in real-time
Kévin Leguay,Barbara Decelle,Yu Yan He,Mireille Hogue,Hiroyuki Kobayashi,Christian Le Gouill,Michel Bouvier,Sébastien Carréno +7 more
TL;DR: Novel BRET-based conformational biosensors are developed and characterized that faithfully monitor ERM activation and can be used to quantify the impact of small molecules, mutation of regulatory amino acids or depletion of upstream regulators on their activity.
Patent
Systems and methods for the monitoring of protein complex formation in cells
TL;DR: In this paper, a bioluminescence resonance energy transfer (BRET) based system and method to monitor ternary complex formation in real-time in live cells with high sensitivity and accuracy is presented.
Journal ArticleDOI
Publisher Correction: Structural insights into binding specificity, efficacy and bias of a β 2 AR partial agonist
Matthieu Masureel,Yaozhong Zou,Louis Picard,Emma T van der Westhuizen,Emma T van der Westhuizen,Jacob P. Mahoney,Jacob P. Mahoney,João P. G. L. M. Rodrigues,Thomas J. Mildorf,Ron O. Dror,Ron O. Dror,David E. Shaw,David E. Shaw,Michel Bouvier,Els Pardon,Jan Steyaert,Roger K. Sunahara,William I. Weis,Cheng Zhang,Brian K. Kobilka +19 more
TL;DR: In the version of this paper originally published, the structure for epinephrine shown in Figure 1a was redrawn with an extra carbon and has been replaced in the HTML and PDF versions of the article.
Journal ArticleDOI
Bradykinin Decreases T-Kininogen Synthesis in a Rat Hepatoma Cell Line: Evidence of Bradykinin B2-Type Receptors
TL;DR: The results support the presence of a functional B2 receptor on H4-II-E-C3 cells that modulates T-kininogen synthesis and suggest that the receptor is involved in vivo in a retroaction loop between kinins and T- Kininogen production during inflammation.