M
Michel Bouvier
Researcher at Université de Montréal
Publications - 412
Citations - 33931
Michel Bouvier is an academic researcher from Université de Montréal. The author has contributed to research in topics: Receptor & G protein-coupled receptor. The author has an hindex of 97, co-authored 396 publications receiving 31267 citations. Previous affiliations of Michel Bouvier include École Polytechnique de Montréal & University of Catania.
Papers
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Journal ArticleDOI
Increased Production of Active Human β2-Adrenergic/Gαs Fusion Receptor in Sf-9 Cells Using Nutrient Limiting Conditions
TL;DR: The results suggest that the increase in the ratio of active/total protein produced results from production under nutrient limitation, and this simple production method should be considered when optimizing expression of G-protein-coupled receptors and other complex proteins.
Book ChapterDOI
Cellular and subcellular context determine outputs from signaling biosensors.
Dominic Devost,Nicolas Audet,Cynthia Zhou,Hiroyuki Kobayashi,Hélène Bonin,Viktorya Lukashova,Christian Le Gouill,Michel Bouvier,Terence E. Hébert +8 more
TL;DR: Concerns about the portability of biosensors between cell types may lead to misinterpretation of drug effects on specific signaling pathways in a given cellular context, and strategies to mitigate these concerns are discussed.
Journal ArticleDOI
Structure-Activity Relationship and Bioactivity of Short Analogues of ELABELA as Agonists of the Apelin Receptor.
Kien Trân,Alexandre Murza,Xavier Sainsily,Eugénie Delile,Pierre Couvineau,Jérôme Côté,David Coquerel,Maude Peloquin,Mannix Auger-Messier,Michel Bouvier,Olivier Lesur,Philippe Sarret,Eric Marsault +12 more
TL;DR: In this article, the authors identified the shortest bioactive C-terminal fragment ELA23-32, which possesses high affinity for APJ and produces cardiorenal effects in vivo similar to those of ELA.
Patent
Double brilliance beta-arrestin: a biosensor for monitoring the activity of receptors and signalling molecules, and method of using same
TL;DR: In this article, an intramolecular bioluminescence resonance energy transfer (BRET) biosensor for monitoring receptor activity and signalling cascades is disclosed, based on double-brilliance.beta.-arrestin between Renilla luciferase (Luc) and the yellow fluorescent protein (YFP).