M
Michel Bouvier
Researcher at Université de Montréal
Publications - 412
Citations - 33931
Michel Bouvier is an academic researcher from Université de Montréal. The author has contributed to research in topics: Receptor & G protein-coupled receptor. The author has an hindex of 97, co-authored 396 publications receiving 31267 citations. Previous affiliations of Michel Bouvier include École Polytechnique de Montréal & University of Catania.
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Journal ArticleDOI
Primary sequence requirements for S-acylation of β2-adrenergic receptor peptides
TL;DR: Results show that short peptides contain the required molecular determinants leading to selective S‐acylation, and whether or not these sequence characteristics also contribute to the selectivity of palmitoylation in vivo will need to be further investigated.
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Functional effects of long-term activation on human β2- and β3-adrenoceptor signalling
TL;DR: Long‐term desensitization may have distinct functional effects on cell signalling depending on the receptor subtype and the cell type considered, and might have practical implications for future strategies involving long‐term therapies with receptor agonists.
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Protein-protein interactions monitored in cells from transgenic mice using bioluminescence resonance energy transfer
TL;DR: This study demonstrates that bioluminescence resonance energy transfer can be used to monitor the dynamic regulation of protein-protein interactions in cells derived from transgenic mice.
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Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response
Besma Benredjem,Jonathan Gallion,Dennis J. Pelletier,Paul Dallaire,Johanie Charbonneau,Darren Cawkill,Karim Nagi,Mark Gosink,Viktoryia Lukasheva,Stephen Jenkinson,Yong Ren,Christopher Somps,Brigitte Murat,Emma T van der Westhuizen,Christian Le Gouill,Olivier Lichtarge,Anne W. Schmidt,Michel Bouvier,Graciela Piñeyro +18 more
TL;DR: Unsupervised clustering of pharmacodynamic parameters are applied to classify GPCR ligands into different categories with similar signaling profiles and shared frequency of report of side effects to associate signals to side effects.
Journal ArticleDOI
Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation.
Bas Brouwers,Edson Mendes de Oliveira,Maria Marti-Solano,Fabiola B.F. Monteiro,Suli-Anne Laurin,Julia M. Keogh,Elana Henning,Rebecca Bounds,Carole A. Daly,Shane Houston,Vikram Ayinampudi,Natalia Wasiluk,David Clarke,Bianca Plouffe,Michel Bouvier,M. Madan Babu,M. Madan Babu,I. Sadaf Farooqi,Jacek Mokrosinski +18 more
TL;DR: In this paper, structural mapping reveals ligand-accessible sites by which MC4R couples to effectors and residues involved in the homodimerization, which is disrupted by multiple obesity-associated mutations.