M
Michel Bouvier
Researcher at Université de Montréal
Publications - 412
Citations - 33931
Michel Bouvier is an academic researcher from Université de Montréal. The author has contributed to research in topics: Receptor & G protein-coupled receptor. The author has an hindex of 97, co-authored 396 publications receiving 31267 citations. Previous affiliations of Michel Bouvier include École Polytechnique de Montréal & University of Catania.
Papers
More filters
Journal ArticleDOI
Palmitoylation of the V2 Vasopressin Receptor Carboxyl Tail Enhances β-Arrestin Recruitment Leading to Efficient Receptor Endocytosis and ERK1/2 Activation
TL;DR: Results indicate that palmitoylation enhances the recruitment of β-arrestin to the activated V2 vasopressin receptor thus facilitating processes requiring the scaffolding action of β, the common link among receptor palMIToylation, endocytosis, and kinase activation.
Journal ArticleDOI
Impedance Responses Reveal β2-Adrenergic Receptor Signaling Pluridimensionality and Allow Classification of Ligands with Distinct Signaling Profiles
TL;DR: It is demonstrated that a single label-free assay based on cellular impedance provides a real-time integration of multiple signaling events engaged upon GPCR activation, indicating that the pluridimensionality of G PCR signaling can be captured using integrative approaches to provide a comprehensive readout of drug activity.
Journal ArticleDOI
Phosphorylation of the rev gene product of human immunodeficiency virus type 1.
TL;DR: The results indicate that the rev protein is posttranslationally modified in vivo and suggest that the level of this modification is subject to modulation by extracellular stimuli.
Journal ArticleDOI
Homo- and Hetero-oligomerization of β-Arrestins in Living Cells
Hélène Storez,Mark G.H. Scott,Hassan Issafras,Anne Burtey,Alexandre Benmerah,Olivier Muntaner,Tristan Piolot,Marc Tramier,Maïté Coppey-Moisan,Michel Bouvier,Catherine Labbé-Jullié,Stefano Marullo +11 more
TL;DR: It is shown that β-arrestins can exist as homo- and hetero-oligomers in living cells and the hypothesis that the oligomeric state may regulate their subcellular distribution and functions is raised.
Journal ArticleDOI
A Novel Biased Allosteric Compound Inhibitor of Parturition Selectively Impedes the Prostaglandin F2α-mediated Rho/ROCK Signaling Pathway *
Eugénie Goupil,Danaë Tassy,Carine B. Bourguet,Christiane Quiniou,Veronica Wisehart,Darlaine Pétrin,Christian Le Gouill,Dominic Devost,Hans H. Zingg,Michel Bouvier,Horacio Uri Saragovi,Sylvain Chemtob,Sylvain Chemtob,William D. Lubell,Audrey Claing,Terence E. Hébert,Stéphane A. Laporte +16 more
TL;DR: Findings regarding the allosteric and biased nature of PDC113.824 offer new mechanistic insights into FP receptor signaling relevant to parturition and suggest novel therapeutic opportunities for the development of new tocolytic drugs.