M
Michel Bouvier
Researcher at Université de Montréal
Publications - 412
Citations - 33931
Michel Bouvier is an academic researcher from Université de Montréal. The author has contributed to research in topics: Receptor & G protein-coupled receptor. The author has an hindex of 97, co-authored 396 publications receiving 31267 citations. Previous affiliations of Michel Bouvier include École Polytechnique de Montréal & University of Catania.
Papers
More filters
Journal ArticleDOI
Functional characterization of vasopressin type 2 receptor substitutions (R137H/C/L) leading to nephrogenic diabetes insipidus and nephrogenic syndrome of inappropriate antidiuresis: implications for treatments.
Moulay Driss Rochdi,Gabriel Vargas,Eric Le Carpentier,Geneviève Oligny-Longpré,Stanford Chen,Abraham Kovoor,Stephen E. Gitelman,Stephen M. Rosenthal,Mark von Zastrow,Michel Bouvier +9 more
TL;DR: Vasopressin was found to promote β-arrestin/AP-2-dependent internalization of R137H/C/L-V2R beyond their already elevated endocytosis levels, raising the possibility that vasopressingin could have a therapeutic value for patients with R137C/ L-V 2R-induced NSIAD by reducing steady-state surface receptor levels, thus lowering basal cAMP production.
Journal ArticleDOI
Biased Signaling of the Mu Opioid Receptor Revealed in Native Neurons.
Aliza T. Ehrlich,Meriem Semache,Florence Gross,Florence Gross,Dillon F. Da Fonte,Leonie Runtz,Christine Colley,Christine Colley,Amina Mezni,Amina Mezni,Christian Le Gouill,Viktoriya Lukasheva,Mireille Hogue,Emmanuel Darcq,Michel Bouvier,Brigitte L. Kieffer +15 more
TL;DR: This work selected a set of clinical and novel mu agonists, and profiled their activities in transfected cell assays using advanced biosensors and in native neurons from knock-in mice expressing traceable receptors endogenously, supporting in vivo translatability of biased signaling for mu opioid drugs.
Journal ArticleDOI
Simultaneous Activation of the δ Opioid Receptor (δOR)/Sensory Neuron-Specific Receptor-4 (SNSR-4) Hetero-Oligomer by the Mixed Bivalent Agonist Bovine Adrenal Medulla Peptide 22 Activates SNSR-4 but Inhibits δOR Signaling
TL;DR: The observation that BAM22 inhibited the Leu-enkephalin-promoted cAMP inhibition in rat dorsal root ganglia neurons supports the potential physiological implication of such regulatory mechanism.
Journal ArticleDOI
Systematic protein-protein interaction mapping for clinically relevant human GPCRs.
Kate Sokolina,Saranya Kittanakom,Jamie Snider,Max Kotlyar,Pascal Maurice,Jorge Gandía,Abla Benleulmi-Chaachoua,Abla Benleulmi-Chaachoua,Abla Benleulmi-Chaachoua,Kenjiro Tadagaki,Kenjiro Tadagaki,Kenjiro Tadagaki,Atsuro Oishi,Atsuro Oishi,Atsuro Oishi,Victoria Wong,Ramy H. Malty,Viktor Deineko,Hiroyuki Aoki,Shahreen Amin,Zhong Yao,Xavier Morató,David Otasek,Hiroyuki Kobayashi,Javier Menendez,Daniel Auerbach,Stephane Angers,Nataša Pržulj,Michel Bouvier,Mohan Babu,Francisco Ciruela,Ralf Jockers,Ralf Jockers,Ralf Jockers,Igor Jurisica,Igor Jurisica,Igor Jurisica,Igor Stagljar +37 more
TL;DR: This work used a modified membrane yeast two‐hybrid approach and identified interacting partners for 48 selected full‐length human ligand‐unoccupied GPCRs in their native membrane environment to obtain a global view of GPCR‐mediated signaling and identify novel components of their pathways.
Journal ArticleDOI
Mutation of tyrosine-141 inhibits insulin-promoted tyrosine phosphorylation and increased responsiveness of the human beta 2-adrenergic receptor.
TL;DR: Results suggest that insulin promotes phosphorylation of the beta 2AR on tyrosine‐141 and that suchosphorylation leads to a supersensitization of the receptor.