M
Michel Bouvier
Researcher at Université de Montréal
Publications - 412
Citations - 33931
Michel Bouvier is an academic researcher from Université de Montréal. The author has contributed to research in topics: Receptor & G protein-coupled receptor. The author has an hindex of 97, co-authored 396 publications receiving 31267 citations. Previous affiliations of Michel Bouvier include École Polytechnique de Montréal & University of Catania.
Papers
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Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells
Mie Fabricius Pedersen,Thor C. Møller,Sofie D. Seiersen,Jesper Mosolff Mathiesen,Michel Bouvier,Hans Bräuner-Osborne +5 more
TL;DR: It is shown that GRK2/3 removal reduced agonist-induced μ-OR internalization and β-arrestin2 recruitment substantially and GRK 2 is found to be more important for these processes than GRK3, and inhibition of GRK1/3 using the small molecule inhibitor CMPD101 showed a high similarity between the genetic and pharmacological approaches, cross-validating the specificity of both.
Patent
Transgenic mouse models for mc4r
TL;DR: In this paper, transgenic non-human animals and cells comprising a transgene encoding either a mutated human melanocortin type-4 receptor (hMC4R) protein, wherein the mutated protein is misfolded and retained intracellularly, or a wild-type human MC4R protein.
Posted ContentDOI
Genetically encoded intrabody sensors illuminate structural and functional diversity in GPCR-β-arrestin complexes
Mithu Baidya,Punita Kumari,Hemlata Dwivedi,Eshan Ghosh,Badr Sokrat,Silvia Sposini,Shubhi Pandey,Tomek Stepniewski,Jana Selent,Aylin C. Hanyaloglu,Michel Bouvier,Arun K. Shukla +11 more
TL;DR: Synthetic intrabody-based conformational sensors reveal a previously unappreciated level of diversity in GPCR-βarr complexes that extends beyond the current framework of affinity-based classification and phosphorylation-code-based interaction patterns and manifests directly in the form of distinct functional outcomes.