M
Michel Bouvier
Researcher at Université de Montréal
Publications - 412
Citations - 33931
Michel Bouvier is an academic researcher from Université de Montréal. The author has contributed to research in topics: Receptor & G protein-coupled receptor. The author has an hindex of 97, co-authored 396 publications receiving 31267 citations. Previous affiliations of Michel Bouvier include École Polytechnique de Montréal & University of Catania.
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Journal ArticleDOI
Conformational dynamics of Kir3.1/Kir3.2 channel activation via δ-opioid receptors.
Mélissa Richard-Lalonde,Karim Nagi,Nicolas Audet,Rory Sleno,Mohammad Amraei,Mireille Hogue,Gianfranco Balboni,Peter W. Schiller,Michel Bouvier,Terence E. Hébert,Graciela Piñeyro +10 more
TL;DR: The fact that BRET changes at the Gβγ-Kir3 interface are predictive of a ligand’s ability to induce channel currents points to these conformational biosensors as screening tools for identifying GPCR ligands that induce Kir3 channel activation.
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Purinergic Receptor Transactivation by the β2-Adrenergic Receptor Increases Intracellular Ca2+ in Nonexcitable Cells.
Wayne Stallaert,Emma T van der Westhuizen,Anne Marie Schönegge,Bianca Plouffe,Mireille Hogue,Viktoria Lukashova,Asuka Inoue,Satoru Ishida,Junken Aoki,Christian Le Gouill,Michel Bouvier +10 more
TL;DR: A model whereby the β2AR stimulates a Gs-dependent release of ATP, which transactivates Gq-coupled P2Y receptors through an inside-out mechanism, leading to a GQ- and IP3-dependent Ca2+ mobilization from intracellular stores is supported.
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Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base.
Lucy Skrabanek,Marta Murcia,Michel Bouvier,Lakshmi A. Devi,Susan R. George,Martin J. Lohse,Graeme Milligan,Richard R. Neubig,Krzysztof Palczewski,Marc Parmentier,Jean-Philippe Pin,Gerrit Vriend,Jonathan A. Javitch,Fabien Campagne,Marta Filizola +14 more
TL;DR: The long term goal is to disseminate to the scientific community organized, curated, and detailed information about GPCR dimerization/oligomerization and its related structural context.
Journal Article
Two kinases mediate agonist-dependent phosphorylation and desensitization of the beta 2-adrenergic receptor.
William P. Hausdorff,Martin J. Lohse,Michel Bouvier,Stephen B. Liggett,M G Caron,Robert J. Lefkowitz +5 more
TL;DR: Phosphorylation of the receptor by both kinases appears to be required for the full desensitization effect seen with the high concentration of agonist, which includes both losses in sensitivity and in the maximal responsiveness of the adenylyl cyclase response upon subsequent challenge with the agonist.
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Chemogenetics defines receptor-mediated functions of short chain free fatty acids.
Daniele Bolognini,Natasja Barki,Adrian J. Butcher,Brian D. Hudson,Eugenia Sergeev,Colin Molloy,Catherine E. Moss,Sophie J. Bradley,Christian Le Gouill,Michel Bouvier,Andrew B. Tobin,Graeme Milligan +11 more
TL;DR: It is determined that activation of FFA2 in differentiated adipocytes and colonic crypt enteroendocrine cells of mouse accounts fully for SCFA-regulated lipolysis and release of the incretin glucagon-like peptide-1 (GLP-1), respectively.