There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality.

Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

I and i

[신간의 별자리x] 우리/미술, 그리고 ‘슬픔의 박물관’

Background: Thyroid nodules are a common clinical problem, and differentiated thyroid cancer is becoming increasingly prevalent. Since the American Thyroid Association's (ATA's) guidelines for the management of these disorders were revised in 2009, significant scientific advances have occurred in the field. The aim of these guidelines is to inform clinicians, patients, researchers, and health policy makers on published evidence relating to the diagnosis and management of thyroid nodules and differentiated thyroid cancer. Methods: The specific clinical questions addressed in these guidelines were based on prior versions of the guidelines, stakeholder input, and input of task force members. Task force panel members were educated on knowledge synthesis methods, including electronic database searching, review and selection of relevant citations, and critical appraisal of selected studies. Published English language articles on adults were eligible for inclusion. The American College of Physicians Guideline Gr...

/pdf/2015-american-thyroid-association-management-guidelines-for-32kri8vrhd.pdf

2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer.

Background: Thyroid nodules are a common clinical problem, and differentiated thyroid cancer is becoming increasingly prevalent. Since the publication of the American Thyroid Association's guidelines for the management of these disorders was published in 2006, a large amount of new information has become available, prompting a revision of the guidelines. Methods: Relevant articles through December 2008 were reviewed by the task force and categorized by topic and level of evidence according to a modified schema used by the United States Preventative Services Task Force. Results: The revised guidelines for the management of thyroid nodules include recommendations regarding initial evaluation, clinical and ultrasound criteria for fine-needle aspiration biopsy, interpretation of fine-needle aspiration biopsy results, and management of benign thyroid nodules. Recommendations regarding the initial management of thyroid cancer include those relating to optimal surgical management, radioiodine remnant ablation, a...

/pdf/revised-american-thyroid-association-management-guidelines-3i6bt8nj9c.pdf

Revised American Thyroid Association Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer

BIOE 402. Medical Technology Assessment. 2 or 3 hours. Bioentrepreneur course. Assessment of medical technology in the context of commercialization. Objectives, competition, market share, funding, pricing, manufacturing, growth, and intellectual property; many issues unique to biomedical products. Course Information: 2 undergraduate hours. 3 graduate hours. Prerequisite(s): Junior standing or above and consent of the instructor.

“Bioinformatics” 특집을 내면서

Editorial [Hot Topic: Nanotechnological and Biotechnological Strategies for Drug Delivery (Guest Editors: Massimiliano Galdiero and Michele Caraglia)]

1245 Zoledronic acid and Taxotere (ZANTE) metronomic and sequential administration in patients with hormone refractory prostate cancer (HRPC) – final results of phase I study

Uratensin-II receptor: A new diagnostic marker and therapeutic target in human prostate adenocarinoma

15173 Background: Local therapies represent a valuable choice in small hepatocellular carcinoma (HCC), however, radiofrequency ablation (RFA) is increasingly used in advanced tumors. Medical treatm...

Tailored combined treatment with radiofrequency ablation plus octreotide in advanced hepatocellular carcinoma

Neuroendocrine differentiation (ND) is widely observed in prostate cancer (PC). Its role in clinical practice is controversial, but preclinical and clinical evidences underline the association of ND with poor prognosis in PC patients. Neuroendocrine (NE) cells could condition the PC progression, mainly stimulating the PC exocrine neoplastic cells proliferation through the production of paracrine growth factors. Thus, the castrated adapted neoplastic cells are favored to outgrowth through an androgen receptor independent mechanism. Moreover proportion of NE cells in PC increases because of tumor treatment, mainly androgen deprivation therapy, enormously amplifying the promotion of the PC exocrine component growth stimulated by neuroendocrine paracrine growth factors.

Michele Caraglia

Papers

Editorial [Hot Topic: Nanotechnological and Biotechnological Strategies for Drug Delivery (Guest Editors: Massimiliano Galdiero and Michele Caraglia)]

1245 Zoledronic acid and Taxotere (ZANTE) metronomic and sequential administration in patients with hormone refractory prostate cancer (HRPC) – final results of phase I study

Uratensin-II receptor: A new diagnostic marker and therapeutic target in human prostate adenocarinoma

Tailored combined treatment with radiofrequency ablation plus octreotide in advanced hepatocellular carcinoma

Neuroendocrine Differentiation in Prostate Cancer