Michele Caraglia

TL;DR: The results suggest that for a correct interpretation of cytotoxicity of nanocarriers, the evaluation of their behavior in biologically relevant conditions is of utmost importance to select proper systems for further in vivo testing.

TL;DR: A reactive mechanism of protection of tumour cells from the apoptosis induced by IFNalpha dependent on the epidermal growth factor-mediated Ras/extracellular signal regulated kinase (Erk) signalling is described, suggesting that the specific disruption of the latter could be a useful approach to potentiate the antitumour activity of IFN alpha against human tumours.

TL;DR: The data suggest that MW‐EMF could have also biochemical and, consequently, biological effects on eukaryotic cells that are still under investigation, and changes in the structural fluctuation caused by MW perturbation can affect differently the aggregation process that occurs competitively during the protein folding, so representing a potential risk for protein “misfolding.

TL;DR: The inhibition of isoprenylation is an attractive, but still not completely investigated therapeutic alternative that requires optimization for the translation in the current treatment of neoplasms.

TL;DR: The purpose of this review is to discuss the most relevant epigenetic and histological prognostic biomarkers in HNC, with particular focus on LC.