M
Michele Caraglia
Researcher at Seconda Università degli Studi di Napoli
Publications - 562
Citations - 24508
Michele Caraglia is an academic researcher from Seconda Università degli Studi di Napoli. The author has contributed to research in topics: Cancer & Cancer cell. The author has an hindex of 67, co-authored 525 publications receiving 20615 citations. Previous affiliations of Michele Caraglia include Temple University & Magna Græcia University.
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Journal ArticleDOI
Synthetic miR-34a Mimics as a Novel Therapeutic Agent for Multiple Myeloma: In Vitro and In Vivo Evidence
Maria Teresa Di Martino,Emanuela Leone,Nicola Amodio,Umberto Foresta,Marta Lionetti,Maria Rita Pitari,Maria Eugenia Gallo Cantafio,Annamaria Gulla,Francesco Conforti,Eugenio Morelli,Vera Tomaino,Marco Rossi,Massimo Negrini,Manlio Ferrarini,Michele Caraglia,Masood A. Shammas,Nikhil C. Munshi,Kenneth C. Anderson,Antonino Neri,Pierosandro Tagliaferri,Pierfrancesco Tassone +20 more
TL;DR: The findings provide a proof-of-principle that formulated synthetic miR-34a has therapeutic activity in preclinical models and support a framework for development of miR -34a–based treatment strategies in MM patients.
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Molecular targets and oxidative stress biomarkers in hepatocellular carcinoma: an overview
Monica Marra,I. Sordelli,Angela Lombardi,Monica Lamberti,Luciano Tarantino,Aldo Giudice,Paola Stiuso,Alberto Abbruzzese,Rossella Sperlongano,Marina Accardo,Massimo Agresti,Michele Caraglia,Pasquale Sperlongano +12 more
TL;DR: The detection of molecular factors predictive of response to anti-cancer agents such as sorafenib and the identification of mechanisms of resistance toAnti- cancer agents may probably represent the direction to improve the treatment of HCC.
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Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism
Massimo Donadelli,Ilaria Dando,T Zaniboni,Chiara Costanzo,E. Dalla Pozza,Maria Teresa Scupoli,Aldo Scarpa,Silvia Zappavigna,M. Marra,Alberto Abbruzzese,Maurizio Bifulco,Michele Caraglia,Michela Palmieri +12 more
TL;DR: Findings support a key role of the ROS-dependent activation of an autophagic program in the synergistic growth inhibition induced by GEM/cannabinoid combination in human pancreatic cancer cells.
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Familial papillary thyroid microcarcinoma: a new clinical entity
Giovanni Lupoli,Giovanni Vitale,Michele Caraglia,M. R. Fittipaldi,Alberto Abbruzzese,Pierosandro Tagliaferri,Angelo Raffaele Bianco +6 more
TL;DR: The unfavourable behaviour in the familial form of papillary thyroid microcarcinoma suggests that radical treatment and careful follow-up are warranted.
Journal ArticleDOI
miR-29b negatively regulates human osteoclastic cell differentiation and function: implications for the treatment of multiple myeloma-related bone disease.
Marco Rossi,Maria Rita Pitari,Nicola Amodio,Maria Teresa Di Martino,Francesco Conforti,Emanuela Leone,Cirino Botta,Francesco Maria Paolino,Teresa Del Giudice,Eleonora Iuliano,Michele Caraglia,Manlio Ferrarini,Antonio Giordano,Antonio Giordano,Pierosandro Tagliaferri,Pierfrancesco Tassone,Pierfrancesco Tassone +16 more
TL;DR: It is found that lentiviral transduction of miR‐29b into OCLs, even in the presence of MM cells, significantly impairs tartrate acid phosphatase (TRAcP) expression, lacunae generation, and collagen degradation, which are relevant hallmarks of OCL activity.