Michele Caraglia

TL;DR: It is shown that the synergistic TIP/DTX combination determines synergistic apoptotic conditions but, at the same time, it modulates the expression of the components of the multichaperone complex that is, in turn, involved in the regulation of the stability of members of the ras‐mediated pathway.

TL;DR: In this paper, the authors summarize the major upregulated and downregulated miRNAs in colitis-associated colorectal cancer and their roles in genes expression modulation in chronic colonic-inflammation-induced carcinogenesis, including programmed cell-death pathways.

TL;DR: The results of the present study highlighted the importance of performing a closer clinical and instrumental follow-up in patients with laryngeal cancer whose histopathological examination is positive for PNI, and it is important to complement the surgical therapeutic treatment with adjuvant RT.

TL;DR: A mechanistic model of theophylline action and anti-tumour strategies based on the concomitant use of thephylline and agents that potentiate tTGase activity can be hypothesized.

TL;DR: A new avenue in anti-cancer treatment has been disclosed with the use of DDS and the different reasons to encapsulate an anti-tumour drug in DDS including eventual damages induced by their extravasation or by eccipients used to their solubilisation, the rapid break-down of the drug in vivo and the specific bio-distribution of theDrug in tumour tissues.