M
Michele Caraglia
Researcher at Seconda Università degli Studi di Napoli
Publications - 562
Citations - 24508
Michele Caraglia is an academic researcher from Seconda Università degli Studi di Napoli. The author has contributed to research in topics: Cancer & Cancer cell. The author has an hindex of 67, co-authored 525 publications receiving 20615 citations. Previous affiliations of Michele Caraglia include Temple University & Magna Græcia University.
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Journal ArticleDOI
Daily low-dose subcutaneous recombinant interleukin-2 by alternate weekly administration: antitumor activity and immunomodulatory effects
Pierosandro Tagliaferri,C. Barile,Michele Caraglia,Rosario Guarrasi,D Morelli,B Ricciardi,A Martignetti,M T Librera,Elide Matano,A Della Vecchia,Giuseppe Catalano,M. Famiani,Giovannella Palmieri,Pierpaolo Correale,Ar Bianco +14 more
TL;DR: It is concluded that this schedule of pulse administration of subcutaneous rIL-2 has antitumor activity in renal cell carcinoma and produces durable biomodulatory effects.
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miR-125b Upregulates miR-34a and Sequentially Activates Stress Adaption and Cell Death Mechanisms in Multiple Myeloma.
Gabriella Misso,Mayra Rachele Zarone,Angela Lombardi,Anna Grimaldi,Alessia Maria Cossu,Carmela Ferri,Margherita Russo,Daniela Cristina Vuoso,Amalia Luce,Hiromichi Kawasaki,Maria Teresa Di Martino,Antonella Virgilio,Agostino Festa,Aldo Galeone,Giuseppe De Rosa,Carlo Irace,Massimo Donadelli,Alois Nečas,Evzen Amler,Pierosandro Tagliaferri,Pierfrancesco Tassone,Michele Caraglia +21 more
TL;DR: This study confirmed an oncosuppressive function depending on the repression of multiple targets, and identified a pattern of miR-125b-co-regulated miRNAs, shedding light on possible new players of anti-MM activity.
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Urotensin-II receptor is over-expressed in colon cancer cell lines and in colon carcinoma in humans
Alessandro Federico,Silvia Zappavigna,Marco Romano,Paolo Grieco,Amalia Luce,Monica Marra,Antonietta Gerarda Gravina,Paola Stiuso,F. P. D'armiento,Giovanni Vitale,Concetta Tuccillo,Ettore Novellino,Carmela Loguercio,Michele Caraglia +13 more
TL;DR: Urotensin (U)‐II receptor (UTR) has been previously reported to be over‐expressed in a number of tumours and whether UTR‐related pathway plays a role in colon carcinogenesis is unknown.
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8-Cl-cAMP antagonizes mitogen-activated protein kinase activation and cell growth stimulation induced by epidermal growth factor.
Alfredo Budillon,E. Di Gennaro,Michele Caraglia,D. Barbarulo,Alberto Abbruzzese,Pierosandro Tagliaferri +5 more
TL;DR: The impairment of KB cell response to EGF, induced by 8-Cl-cAMP, resides in the specific inhibition of MAPK/ERKs activity while the function of the upstream elements in the EGF-R signalling is preserved.
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Nanotechnologies: New Opportunities for Old Drugs. The Case of Aminobisphosphonates
TL;DR: Several preclinical evidence has suggested that NBP has pleiotropic anti- cancer effects inducing apoptosis and cell growth arrest and inhibiting invasion and metastatic processes and potentiating the anti-cancer immune response through Tγ/δ lymphocyte proliferation.