M
Michele Caraglia
Researcher at Seconda Università degli Studi di Napoli
Publications - 562
Citations - 24508
Michele Caraglia is an academic researcher from Seconda Università degli Studi di Napoli. The author has contributed to research in topics: Cancer & Cancer cell. The author has an hindex of 67, co-authored 525 publications receiving 20615 citations. Previous affiliations of Michele Caraglia include Temple University & Magna Græcia University.
Papers
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Journal ArticleDOI
The 1,4 benzoquinone-featured 5-lipoxygenase inhibitor RF-Id induces apoptotic death through downregulation of IAPs in human glioblastoma cells
Silvia Zappavigna,Maria Scuotto,Alessia Maria Cossu,Diego Ingrosso,M. De Rosa,Chiara Schiraldi,Rosanna Filosa,Michele Caraglia +7 more
TL;DR: RF-Id induced a caspase-dependent apoptosis in GBM cells by inhibiting IAP family proteins and NFκB pathway and represents a promising lead compound for designing a new class of anti-cancer drugs with multiple targets.
Book ChapterDOI
Measurement of Autophagy by Flow Cytometry.
TL;DR: In vitro methods currently available to detect autophagic cell death by flow cytometry analysis are detailed, including quantitative methods for the detection of cytoplasmic protein turnover and the identification of autophagosomes.
Journal ArticleDOI
Keratin 5 expression in squamocellular carcinoma of the head and neck
Virgil Vasca,Elisabeta Maria Vasca,Paul Freiman,Diana Marian,Amalia Luce,Massimo Mesolella,Michele Caraglia,Filippo Ricciardiello,Tatiana Duminica +8 more
TL;DR: Keratin 5 expression was observed in all squamocellular carcinomas included in the present study with scores between 1 and 3, and these observations may aid with an improved stratification of head and neck squamocells carcinoma, thus improving the diagnosis and treatment strategies for this type of cancer.
Journal ArticleDOI
Assessment of Total, PTEN-, and AR-V7+ Circulating Tumor Cell Count by Flow Cytometry in Patients with Metastatic Castration-Resistant Prostate Cancer Receiving Enzalutamide.
Giuseppe Di Lorenzo,Silvia Zappavigna,Felice Crocetto,Mario Giuliano,Dario Ribera,Rocco Morra,Luca Scafuri,Antonio Verde,Dario Bruzzese,Simona Iaccarino,Ferdinando Costabile,Livia Onofrio,Martina Viggiani,Alessandro Palmieri,Pietro De Placido,Antonella Lucia Marretta,Erica Pietroluongo,Amalia Luce,Marianna Abate,Zahrasadat Navaeiseddighi,Vincenzo Caputo,Giuseppe Celentano,Nicola Longo,Matteo Ferro,Franco Morelli,Gaetano Facchini,Michele Caraglia,Sabino De Placido,Carlo Buonerba +28 more
TL;DR: It is found that flow cytometry could be used to enumerate circulating tumor cells, but also to assess molecular biomarkers on their surface to provide potentially useful prognostic and predictive information in advanced prostate cancer.
Journal ArticleDOI
Levofolene modulates apoptosis induced by 5-fluorouracil through autophagy inhibition: clinical and occupational implications.
Monica Lamberti,Stefania Porto,Silvia Zappavigna,Paola Stiuso,Virginia Tirino,Vincenzo Desiderio,Luigi Mele,Michele Caraglia +7 more
TL;DR: It is suggested for the first time that LF potentiates the cytotoxicity of 5-FU on keratinocytes likely through the antagonism on autophagy escape pathway and consequent apoptosis potentiation.