Sarah Becker

TL;DR: It is found that malignant cells in glioblastoma exist in four main cellular states that recapitulate distinct neural cell types, are influenced by the tumor microenvironment, and exhibit plasticity.

TL;DR: Single-cell RNA sequencing is used to reveal molecular hallmarks of the disease that might be targeted therapeutically in Pilocytic astrocytoma, indicating that MAPK signaling is restricted to relatively undifferentiated cancer cells in PA.

TL;DR: The feasibility of profiling pediatric brain tumors using ctDNA obtained from plasma, cerebrospinal fluid (CSF) and urine, and a pediatric CNS tumor hybrid-capture panel for deep sequencing of specific mutations and fusions is evaluated.

TL;DR: The iMASC system was shown to successfully fit multiple different face sizes and shapes using an OSHA-approved testing method, and these data support further certification testing needed for use in the healthcare setting.

TL;DR: In this paper , the role of PPM1D mutations in de novo gliomagenesis has been systematically explored, and it was shown that truncating mutations in PPM 1D that increase the stability of its phosphatase are clonal driver events in 11% of Diffuse Midline Gliomas (DMGs) and are enriched in primary pontine tumors.