M
Marni E. Shore
Researcher at Harvard University
Publications - 6
Citations - 1729
Marni E. Shore is an academic researcher from Harvard University. The author has contributed to research in topics: Synovial sarcoma & Immune system. The author has an hindex of 5, co-authored 6 publications receiving 760 citations. Previous affiliations of Marni E. Shore include Broad Institute.
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Journal ArticleDOI
An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma
Cyril Neftel,Julie Laffy,Mariella G. Filbin,Toshiro Hara,Marni E. Shore,Marni E. Shore,Gilbert J. Rahme,Gilbert J. Rahme,Alyssa R. Richman,Alyssa R. Richman,Dana Silverbush,Dana Silverbush,McKenzie Shaw,Christine M. Hebert,Christine M. Hebert,John M. DeWitt,John M. DeWitt,Simon Gritsch,Simon Gritsch,Elizabeth M. Perez,Elizabeth M. Perez,L. Nicolas Gonzalez Castro,Xiaoyang Lan,Xiaoyang Lan,Nicholas Druck,Christopher Rodman,Danielle Dionne,Alexander Kaplan,Mia Bertalan,Julia L. Small,Kristine Pelton,Sarah Becker,Dennis M. Bonal,Quang-Dé Nguyen,Rachel L. Servis,Jeremy M. Fung,Ravindra Mylvaganam,Lisa Mayr,Johannes Gojo,Christine Haberler,René Geyeregger,Thomas Czech,Irene Slavc,Brian V. Nahed,William T. Curry,Bob S. Carter,Hiroaki Wakimoto,Priscilla K. Brastianos,Tracy T. Batchelor,Anat Stemmer-Rachamimov,Maria Martinez-Lage,Matthew P. Frosch,Ivan Stamenkovic,Nicolo Riggi,Esther Rheinbay,Esther Rheinbay,Michelle Monje,Orit Rozenblatt-Rosen,Daniel P. Cahill,Anoop P. Patel,Tony Hunter,Inder M. Verma,Keith L. Ligon,Keith L. Ligon,David N. Louis,Aviv Regev,Aviv Regev,Bradley E. Bernstein,Bradley E. Bernstein,Itay Tirosh,Mario L. Suvà,Mario L. Suvà +71 more
TL;DR: It is found that malignant cells in glioblastoma exist in four main cellular states that recapitulate distinct neural cell types, are influenced by the tumor microenvironment, and exhibit plasticity.
Journal ArticleDOI
Resolving medulloblastoma cellular architecture by single-cell genomics
Volker Hovestadt,Volker Hovestadt,Kyle S. Smith,Laure Bihannic,Mariella G. Filbin,Mariella G. Filbin,Mariella G. Filbin,McKenzie Shaw,McKenzie Shaw,McKenzie Shaw,Alicia Baumgartner,Alicia Baumgartner,John C. DeWitt,John C. DeWitt,Andrew P Groves,Lisa Mayr,Hannah R. Weisman,Hannah R. Weisman,Alyssa R. Richman,Alyssa R. Richman,Marni E. Shore,Marni E. Shore,Liliana Goumnerova,Celeste Rosencrance,Robert A. Carter,Timothy N. Phoenix,Jennifer Hadley,Yiai Tong,Jim Houston,Richard A. Ashmun,Michael DeCuypere,Tanvi Sharma,Diane Flasch,Antonina Silkov,Keith L. Ligon,Keith L. Ligon,Scott L. Pomeroy,Miguel Rivera,Miguel Rivera,Orit Rozenblatt-Rosen,Orit Rozenblatt-Rosen,Jessica M. Rusert,Robert J. Wechsler-Reya,Xiao-Nan Li,Andreas Peyrl,Johannes Gojo,Dominik Kirchhofer,Daniela Lötsch,Thomas Czech,Christian Dorfer,Christine Haberler,René Geyeregger,René Geyeregger,Angela Halfmann,Charles Gawad,John Easton,Stefan M. Pfister,Stefan M. Pfister,Aviv Regev,Aviv Regev,Amar Gajjar,Brent A. Orr,Irene Slavc,Giles W. Robinson,Bradley E. Bernstein,Bradley E. Bernstein,Mario L. Suvà,Mario L. Suvà,Paul A. Northcott +68 more
TL;DR: Characterization of medulloblastoma tissues using single-cell transcriptomics shows that the different molecular subtypes consist of distinct developmental phenotypes, which provides insights into the cellular and developmental states underlying subtype-specific medullOBlastoma biology.
Journal ArticleDOI
Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis
Nathan Mathewson,Orr Ashenberg,Itay Tirosh,Simon Gritsch,Simon Gritsch,Elizabeth M. Perez,Sascha Marx,Livnat Jerby-Arnon,Rony Chanoch-Myers,Toshiro Hara,Toshiro Hara,Alyssa R. Richman,Alyssa R. Richman,Yoshinaga Ito,Jason Pyrdol,Mirco Friedrich,Kathrin Schumann,Kathrin Schumann,Michael J. Poitras,Prafulla C. Gokhale,L. Nicolas Gonzalez Castro,Marni E. Shore,Marni E. Shore,Christine M. Hebert,Christine M. Hebert,Brian A. Shaw,Heather L. Cahill,Matthew Drummond,Wubing Zhang,Olamide Olawoyin,Hiroaki Wakimoto,Orit Rozenblatt-Rosen,Orit Rozenblatt-Rosen,Priscilla K. Brastianos,X. Shirley Liu,Pamela S. Jones,Daniel P. Cahill,Matthew P. Frosch,David N. Louis,Gordon J. Freeman,Keith L. Ligon,Alexander Marson,Alexander Marson,E. Antonio Chiocca,David A. Reardon,David A. Reardon,Aviv Regev,Mario L. Suvà,Mario L. Suvà,Kai W. Wucherpfennig +49 more
TL;DR: In this paper, single-cell RNA sequencing (RNA-seq) was used to chart the gene expression and clonal landscape of tumor-infiltrating T cells across 31 patients with isocitrate dehydrogenase (IDH) wild-type glioblastoma and IDH mutant glioma.
Journal ArticleDOI
Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma.
Johannes Gojo,Johannes Gojo,Bernhard Englinger,Bernhard Englinger,Li Jiang,Li Jiang,Jens Martin Hübner,McKenzie Shaw,McKenzie Shaw,Olivia A Hack,Olivia A Hack,Sibylle Madlener,Dominik Kirchhofer,Ilon Liu,Ilon Liu,Jason Pyrdol,Volker Hovestadt,Volker Hovestadt,Emanuele Mazzola,Nathan Mathewson,Maria Trissal,Maria Trissal,Daniela Lötsch,Christian Dorfer,Christine Haberler,Angela Halfmann,Lisa Mayr,Andreas Peyrl,René Geyeregger,Benjamin Schwalm,Monica Mauermann,Kristian W. Pajtler,Kristian W. Pajtler,Till Milde,Marni E. Shore,Marni E. Shore,Jack Geduldig,Kristine Pelton,Thomas Czech,Orr Ashenberg,Kai W. Wucherpfennig,Orit Rozenblatt-Rosen,Sanda Alexandrescu,Keith L. Ligon,Keith L. Ligon,Keith L. Ligon,Stefan M. Pfister,Stefan M. Pfister,Aviv Regev,Aviv Regev,Irene Slavc,Walter Berger,Mario L. Suvà,Mario L. Suvà,Marcel Kool,Mariella G. Filbin,Mariella G. Filbin +56 more
TL;DR: Single-cell RNA sequencing is applied to analyze ependymomas across molecular groups and anatomic locations to investigate their intratumoral heterogeneity and developmental origins, revealing a developmental hierarchy underlying ependylomas relevant to biological and clinical behavior.
Journal ArticleDOI
Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma
Livnat Jerby-Arnon,Cyril Neftel,Marni E. Shore,Marni E. Shore,Hannah R. Weisman,Hannah R. Weisman,Nathan Mathewson,Nathan Mathewson,Matthew J. McBride,Brian J. Haas,Benjamin Izar,Benjamin Izar,Angela Volorio,Angela Volorio,Gaylor Boulay,Gaylor Boulay,Luisa Cironi,Alyssa R. Richman,Alyssa R. Richman,Liliane C. Broye,Joseph M. Gurski,Christina C. Luo,Ravindra Mylvaganam,Lan Nguyen,Shaolin Mei,Johannes C. Melms,Christophe H. Georgescu,Ofir Cohen,Ofir Cohen,Jorge E. Buendia-Buendia,Asa Segerstolpe,Malika Sud,Michael S. Cuoco,Michael S. Cuoco,Danny Labes,Simon Gritsch,Simon Gritsch,Daniel R. Zollinger,Nicole Ortogero,Joseph M. Beechem,G. Petur Nielsen,Ivan Chebib,Tu Nguyen-Ngoc,Michael Montemurro,Gregory M. Cote,Edwin Choy,Igor Letovanec,Stéphane Cherix,Nikhil Wagle,Nikhil Wagle,Peter K. Sorger,Alex B. Haynes,John T. Mullen,Ivan Stamenkovic,Miguel Rivera,Miguel Rivera,Cigall Kadoch,Cigall Kadoch,Kai W. Wucherpfennig,Kai W. Wucherpfennig,Orit Rozenblatt-Rosen,Orit Rozenblatt-Rosen,Mario L. Suvà,Mario L. Suvà,Nicolo Riggi,Nicolo Riggi,Aviv Regev +66 more
TL;DR: In this article, the authors studied the cancer-immune interplay in synovial sarcoma using an integrative approach that combines single-cell RNA sequencing (scRNA-seq), spatial profiling and genetic and pharmacological perturbations.