M
Mireille Lambert
Researcher at University of Paris
Publications - 44
Citations - 3325
Mireille Lambert is an academic researcher from University of Paris. The author has contributed to research in topics: Cadherin & Myeloid leukemia. The author has an hindex of 27, co-authored 40 publications receiving 3035 citations. Previous affiliations of Mireille Lambert include French Institute of Health and Medical Research & Centre national de la recherche scientifique.
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Journal ArticleDOI
Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibition.
Nathalie Jacque,Anne Marie Ronchetti,Clément Larrue,Clément Larrue,Godelieve Meunier,Rudy Birsen,Lise Willems,Estelle Saland,Estelle Saland,Justine Decroocq,Thiago Trovati Maciel,Mireille Lambert,Laury Poulain,Pierre Sujobert,Laure Joseph,Nicolas Chapuis,Nicolas Chapuis,Catherine Lacombe,Catherine Lacombe,Ivan C. Moura,Susan Demo,Jean-Emmanuel Sarry,Jean-Emmanuel Sarry,Christian Recher,Christian Recher,Patrick Mayeux,Patrick Mayeux,Jerome Tamburini,Didier Bouscary +28 more
TL;DR: It is shown that glutamine levels control mitochondrial oxidative phosphorylation (OXPHOS) in acute myeloid leukemia (AML) cells and targeting glutamine addiction via GLS1 inhibition offers a potential novel therapeutic strategy for AML.
Journal ArticleDOI
Regulation of cell-cell junctions by the cytoskeleton.
TL;DR: This work has revealed the important contribution of acto-myosin, microtubules and cell tension to adherens junction formation, cell differentiation and tissue reshaping/remodeling in animal cell-cell adhesion.
Journal ArticleDOI
Strength Dependence of Cadherin-Mediated Adhesions
Benoit Ladoux,Benoit Ladoux,Ester Anon,Mireille Lambert,Mireille Lambert,Aleksandr Rabodzey,Pascal Hersen,Axel Buguin,Axel Buguin,Pascal Silberzan,René-Marc Mège,René-Marc Mège +11 more
TL;DR: A quantitative analysis of the cells adhering on the cadherin-coated surfaces shows that forces are correlated with the formation of Cadherin adhesions, and these findings are consistent with a mechanosensitive regulation of cadher in-mediated intercellular junctions through the cellular contractile machinery.
Journal ArticleDOI
Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia.
Lise Willems,Lise Willems,Nathalie Jacque,Arnaud Jacquel,Nathalie Neveux,Thiago Trovati Maciel,Mireille Lambert,Alain Schmitt,Laury Poulain,Alexa S. Green,Madalina Uzunov,Olivier Kosmider,Olivier Kosmider,Isabelle Radford-Weiss,Ivan C. Moura,Patrick Auberger,Norbert Ifrah,Valérie Bardet,Valérie Bardet,Nicolas Chapuis,Nicolas Chapuis,Catherine Lacombe,Catherine Lacombe,Patrick Mayeux,Patrick Mayeux,Jerome Tamburini,Jerome Tamburini,Didier Bouscary,Didier Bouscary +28 more
TL;DR: It is shown that glutamine removal inhibits mTORC1 and induces apoptosis in AML cells, and that l-ases upregulate glutamine synthase expression in leukemic cells and that a GS knockdown enhances l-ase-induced apoptotic response in someAML cells.
Journal ArticleDOI
Traction forces exerted through N-cadherin contacts.
Arthur Ganz,Mireille Lambert,Alexandre Saez,Pascal Silberzan,A. Buguin,René-Marc Mège,Benoit Ladoux +6 more
TL;DR: The present study focuses on the determination of force transduction through cadherins at a single cell level and the role of adherens junctions in force‐regulation processes.