Mohammad S. Radi

TL;DR: This work demonstrates increased tolerance towards and growth rate at the expense of hydroxycinnamic acids and presents new targets for improving P. putida for microbial lignin valorization.

TL;DR: Adaptive laboratory evolution was used to explore the tolerance mechanisms that Saccharomyces cerevisiae can evolve in the presence of inhibiting concentrations of three dicarboxylic acids, and the amplification of QDR3 was shown to confer tolerance towards muconic acid and glutaconic acid.

TL;DR: It is shown that regulating the activity of transporters is a major mechanism to improve tolerance to aromatic acids and can be used to modulate the intracellular concentration of aromatic compounds to optimize the excretion of such products while keeping precursor molecules inside the cell.

TL;DR: In this paper, a strategy of adaptive laboratory evolution in hydrolysate-based medium was developed to improve the tolerance of Rhodosporidium toruloides to inhibitors present in biomass hydro-lysate.

TL;DR: In this paper , adaptive laboratory evolution was leveraged to identify membrane transporters for a set of four amino acids as well as specific mutations that modulate the activities of these transporter.