M
Monica Casali
Researcher at Broad Institute
Publications - 4
Citations - 450
Monica Casali is an academic researcher from Broad Institute. The author has contributed to research in topics: Viral evolution & Sequence assembly. The author has an hindex of 3, co-authored 4 publications receiving 436 citations. Previous affiliations of Monica Casali include University of New Mexico.
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Journal ArticleDOI
Whole genome deep sequencing of HIV-1 reveals the impact of early minor variants upon immune recognition during acute infection
Matthew R. Henn,Christian L. Boutwell,Patrick Charlebois,Niall J. Lennon,Karen A. Power,Alexander R. Macalalad,Aaron M. Berlin,Christine M. Malboeuf,Elizabeth M. Ryan,Sante Gnerre,Michael C Zody,Rachel L. Erlich,Lisa Green,Andrew Berical,Yaoyu E. Wang,Monica Casali,Hendrik Streeck,Allyson K. Bloom,Tim Dudek,Damien C. Tully,Ruchi M. Newman,Karen L. Axten,Adrianne D. Gladden,Laura Battis,Michael Kemper,Qiandong Zeng,Terrance Shea,Sharvari Gujja,Carmen Zedlack,Olivier Gasser,Christian Brander,Christoph Hess,Huldrych F. Günthard,Zabrina L. Brumme,Chanson J. Brumme,Suzane Bazner,Jenna Rychert,Jake P. Tinsley,Kenneth H. Mayer,Eric S. Rosenberg,Florencia Pereyra,Joshua Z. Levin,Sarah Young,Heiko Jessen,Marcus Altfeld,Bruce W. Birren,Bruce D. Walker,Bruce D. Walker,Todd M. Allen +48 more
TL;DR: It is concluded that the early control of HIV-1 replication by immunodominant CD8+ T cell responses may be substantially influenced by rapid, low frequency viral adaptations not detected by conventional sequencing approaches, which warrants further investigation.
Journal ArticleDOI
Complete viral RNA genome sequencing of ultra-low copy samples by sequence-independent amplification
Christine M. Malboeuf,Xiao Yang,Patrick Charlebois,James Qu,Aaron M. Berlin,Monica Casali,Kendra N. Pesko,Christian L. Boutwell,John P. DeVincenzo,Gregory D. Ebel,Todd M. Allen,Michael C. Zody,Matthew R. Henn,Joshua Z. Levin +13 more
TL;DR: With 5 million reads, this study captures 96 to 100% of the viral protein coding region of HIV, respiratory syncytial and West Nile viral samples from as little as 100 copies of viral RNA.
Journal ArticleDOI
P09-20 LB. Ultra-deep sequencing of full-length HIV-1 genomes identifies rapid viral evolution during acute infection
Henn,C Boutwell,Niall J. Lennon,Karen A. Power,Christine M. Malboeuf,Patrick Charlebois,Andrew B. Gladden,Joshua Z. Levin,Monica Casali,L Philips,Aaron M. Berlin,Andrew Berical,Rachel L. Erlich,Scott Anderson,Hendrik Streeck,M Kemper,Elizabeth P. Ryan,Yaoyu E. Wang,Lisa Green,K Axten,Zabrina L. Brumme,Chanson J. Brumme,Carsten Russ,Eric S. Rosenberg,Heiko Jessen,Marcus Altfeld,Chad Nusbaum,Bruce D. Walker,Bruce W. Birren,Todd M. Allen +29 more
TL;DR: Ultra-deep sequencing of full-length HIV-1 genomes identifies rapid viral evolution during acute infection.
Journal ArticleDOI
Sensitive population profiling and genome assembly of HIV and Flaviviruses using ultra-deep sequencing technologies
Matthew R. Henn,Niall J. Lennon,Ruchi M. Newman,Patrick Charlebois,Christian L. Boutwell,Molly OhAinle,Aaron M. Berlin,Elizabeth P. Ryan,Christine M. Malboeuf,Alex Macalalad,Monica Casali,Rachel L. Erlich,Henry Bigelow,Lisa Green,Sante Gnerre,Sarah Young,Joshua Z. Levin,Chad Nusbaum,Bruce D. Walker,Michael S. Diamond,Laura D. Kramer,Gregory D. Ebel,Eva Harris,Todd M. Allen,Bruce W. Birren +24 more
TL;DR: The power of scalable, next generation sequencing-based methodologies as a genome-wide and unbiased global approach to profiling genomic diversity in intra-host populations of single stranded RNA viruses is demonstrated.