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Adrianne D. Gladden
Researcher at Ragon Institute of MGH, MIT and Harvard
Publications - 12
Citations - 1479
Adrianne D. Gladden is an academic researcher from Ragon Institute of MGH, MIT and Harvard. The author has contributed to research in topics: Viral replication & Epitope. The author has an hindex of 10, co-authored 12 publications receiving 1378 citations. Previous affiliations of Adrianne D. Gladden include Massachusetts Institute of Technology & Harvard University.
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Journal ArticleDOI
Whole genome deep sequencing of HIV-1 reveals the impact of early minor variants upon immune recognition during acute infection
Matthew R. Henn,Christian L. Boutwell,Patrick Charlebois,Niall J. Lennon,Karen A. Power,Alexander R. Macalalad,Aaron M. Berlin,Christine M. Malboeuf,Elizabeth M. Ryan,Sante Gnerre,Michael C Zody,Rachel L. Erlich,Lisa Green,Andrew Berical,Yaoyu E. Wang,Monica Casali,Hendrik Streeck,Allyson K. Bloom,Tim Dudek,Damien C. Tully,Ruchi M. Newman,Karen L. Axten,Adrianne D. Gladden,Laura Battis,Michael Kemper,Qiandong Zeng,Terrance Shea,Sharvari Gujja,Carmen Zedlack,Olivier Gasser,Christian Brander,Christoph Hess,Huldrych F. Günthard,Zabrina L. Brumme,Chanson J. Brumme,Suzane Bazner,Jenna Rychert,Jake P. Tinsley,Kenneth H. Mayer,Eric S. Rosenberg,Florencia Pereyra,Joshua Z. Levin,Sarah Young,Heiko Jessen,Marcus Altfeld,Bruce W. Birren,Bruce D. Walker,Bruce D. Walker,Todd M. Allen +48 more
TL;DR: It is concluded that the early control of HIV-1 replication by immunodominant CD8+ T cell responses may be substantially influenced by rapid, low frequency viral adaptations not detected by conventional sequencing approaches, which warrants further investigation.
Journal ArticleDOI
Clinical Sequencing Uncovers Origins and Evolution of Lassa Virus
Kristian G. Andersen,Kristian G. Andersen,Kristian G. Andersen,B. Jesse Shapiro,B. Jesse Shapiro,B. Jesse Shapiro,Christian B. Matranga,Rachel Sealfon,Rachel Sealfon,Aaron E. Lin,Aaron E. Lin,Lina M. Moses,Onikepe A. Folarin,Augustine Goba,Ikponmwonsa Odia,Philomena E. Ehiane,Mambu Momoh,Eleina M. England,Sarah Winnicki,Sarah Winnicki,Luis M. Branco,Stephen K. Gire,Stephen K. Gire,Eric Phelan,Ridhi Tariyal,Ryan Tewhey,Ryan Tewhey,Omowunmi Omoniwa,Mohammed Fullah,Richard Fonnie,Mbalu Fonnie,Lansana Kanneh,Simbirie Jalloh,Michael Gbakie,Sidiki Saffa,Kandeh Karbo,Adrianne D. Gladden,James Qu,Matthew Stremlau,Matthew Stremlau,Mahan Nekoui,Mahan Nekoui,Hilary K. Finucane,Shervin Tabrizi,Shervin Tabrizi,Joseph J. Vitti,Bruce W. Birren,Michael Fitzgerald,Caryn McCowan,Andrea T. Ireland,Aaron M. Berlin,James Bochicchio,Barbara Tazon-Vega,Niall J. Lennon,Elizabeth M. Ryan,Zach Bjornson,Danny A. Milner,Amanda K. Lukens,Nisha Broodie,Megan M. Rowland,Megan L. Heinrich,Marjan Akdag,John S. Schieffelin,Danielle C Levy,Henry Akpan,Daniel G. Bausch,Kathleen Rubins,Joseph B. McCormick,Eric S. Lander,Stephan Günther,Lisa E. Hensley,Sylvanus Okogbenin,Stephen F. Schaffner,Peter O. Okokhere,S. Humarr Khan,Donald S. Grant,George O. Akpede,Danny Asogun,Andreas Gnirke,Joshua Z. Levin,Christian T. Happi,Robert F. Garry,Pardis C. Sabeti,Pardis C. Sabeti +83 more
TL;DR: In this paper, a genomic catalog of almost 200 Lassa virus (LASV) sequences from clinical and rodent reservoir samples was generated, showing that whereas the 2013-2015 West African epidemic of Ebola virus disease (EVD) was fueled by human-to-human transmissions, LASV infections mainly result from reservoir-tohuman infections.
Journal ArticleDOI
Vaccine-induced CD8 + T cells control AIDS virus replication
Philip A. Mudd,Mauricio A. Martins,Adam J. Ericsen,Damien C. Tully,Karen A. Power,Alex T. Bean,Shari M. Piaskowski,Lijie Duan,Aaron M. Seese,Adrianne D. Gladden,Kim L. Weisgrau,Jessica Furlott,Young-il Kim,Marlon G. Veloso de Santana,Eva G. Rakasz,Saverio Capuano,Nancy A. Wilson,Myrna C. Bonaldo,Ricardo Galler,David B. Allison,Michael Piatak,Ashley T. Haase,Jeffrey D. Lifson,Todd M. Allen,David I. Watkins +24 more
TL;DR: These findings indicate that narrowly targeted vaccine-induced virus-specific CD8+ T-cell responses can control replication of the AIDS virus.
Journal ArticleDOI
Rapid Reversion of Sequence Polymorphisms Dominates Early Human Immunodeficiency Virus Type 1 Evolution
Bin Li,Adrianne D. Gladden,Marcus Altfeld,John M. Kaldor,David A. Cooper,Anthony D. Kelleher,Todd M. Allen +6 more
TL;DR: The propensity of mutations to revert may limit the accumulation of immune pressure-driven mutations in the population, thus preserving critical CD8+ T-cell epitopes as vaccine targets, and argue against an unremitting adaptation of HIV-1 to host immune pressures.
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Protective HLA Class I Alleles That Restrict Acute-Phase CD8+ T-Cell Responses Are Associated with Viral Escape Mutations Located in Highly Conserved Regions of Human Immunodeficiency Virus Type 1
Yaoyu E. Wang,Bin Li,Jonathan M. Carlson,Hendrik Streeck,Adrianne D. Gladden,Robert L. Goodman,Arne Schneidewind,Karen A. Power,Ildiko Toth,Nicole Frahm,Galit Alter,Christian Brander,Mary Carrington,Bruce D. Walker,Bruce D. Walker,Marcus Altfeld,David Heckerman,Todd M. Allen +17 more
TL;DR: It is suggested that control of HIV-1 may be associated with acute-phase CD8 responses capable of selecting for viral escape mutations in highly conserved regions of the virus, supporting the inclusion of these regions in the design of an effective vaccine.