M
Moritz Haneklaus
Researcher at Trinity College, Dublin
Publications - 13
Citations - 5918
Moritz Haneklaus is an academic researcher from Trinity College, Dublin. The author has contributed to research in topics: Inflammasome & Innate immune system. The author has an hindex of 10, co-authored 11 publications receiving 4442 citations.
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Journal ArticleDOI
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
Gillian M. Tannahill,Anne M. Curtis,Juraj Adamik,Eva M. Palsson-McDermott,Anne F. McGettrick,Gautam Goel,Christian Frezza,Nicholas J. Bernard,Beth Kelly,Niamh Foley,Liang Zheng,A. Gardet,Zhen Tong,S. S. Jany,Sinéad C. Corr,Moritz Haneklaus,Brian E. Caffrey,Kerry A. Pierce,Sarah R. Walmsley,F. C. Beasley,Eoin P. Cummins,Victor Nizet,Moira K. B. Whyte,Cormac T. Taylor,Hening Lin,Seth L. Masters,Eyal Gottlieb,Vincent P. Kelly,Clary B. Clish,Philip E. Auron,Ramnik J. Xavier,Ramnik J. Xavier,Luke A. J. O'Neill +32 more
TL;DR: The authors showed that inhibition of glycolysis with 2-deoxyglucose suppresses lipopolysaccharide-induced interleukin-1β but not tumour-necrosis factor-α in mouse macrophages.
Journal ArticleDOI
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
Rebecca C. Coll,Avril A. B. Robertson,Jae Jin Chae,Sarah C. Higgins,Raúl Muñoz-Planillo,Marco Inserra,Irina Vetter,Lara S. Dungan,Brian G. Monks,Andrea Stutz,Daniel E. Croker,Mark S. Butler,Moritz Haneklaus,Caroline E. Sutton,Gabriel Núñez,Eicke Latz,Daniel L. Kastner,Kingston H. G. Mills,Seth L. Masters,Kate Schroder,Mark E. Cooper,Luke A. J. O'Neill +21 more
TL;DR: MCC950 treatment rescued neonatal lethality in a mouse model of CAPS and was active in ex vivo samples from individuals with Muckle–Wells syndrome, and is a potential therapeutic for NLRP3-associated syndromes, and a tool for further study of theNLRP3 inflammasome in human health and disease.
Journal ArticleDOI
Cutting Edge: miR-223 and EBV miR-BART15 Regulate the NLRP3 Inflammasome and IL-1β Production
Moritz Haneklaus,Motti Gerlic,Mariola Kurowska-Stolarska,Ashleigh-Ann Rainey,Dagmar Pich,Iain B. McInnes,Wolfgang Hammerschmidt,Luke A. J. O'Neill,Seth L. Masters,Seth L. Masters +9 more
TL;DR: The first endogenous miRNA is identified that limits NLRP3 inflammatory capacity during myeloid cell development and also a viral miRNA that takes advantage of this, limiting inflammation for its own purposes.
Journal ArticleDOI
miR‐223: infection, inflammation and cancer
Moritz Haneklaus,Motti Gerlic,Motti Gerlic,Luke A. J. O'Neill,Seth L. Masters,Seth L. Masters +5 more
TL;DR: It is shown how the microRNA miR‐223 modulates inflammation, infection and cancer development, and NF‐κB and the NLRP3 inflammasome are important inflammatory mechanisms that are dampened by miR-223 in these cell types.
Journal ArticleDOI
Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome
Viola Neudecker,Viola Neudecker,Moritz Haneklaus,Owen Jensen,Ludmila Khailova,Joanne C. Masterson,Joanne C. Masterson,Hazel Tye,Hazel Tye,Kathryn A. Biette,Kathryn A. Biette,Paul Jedlicka,Kelley S. Brodsky,Mark E. Gerich,Matthias Mack,Avril A. B. Robertson,Mark E. Cooper,Glenn T. Furuta,Glenn T. Furuta,Charles A. Dinarello,Charles A. Dinarello,Luke A. J. O'Neill,Holger K. Eltzschig,Holger K. Eltzschig,Seth L. Masters,Seth L. Masters,Eóin N. McNamee +26 more
TL;DR: It is reported that miR-223 limits intestinal inflammation by constraining the nlrp3 inflammasome in mice, revealing a previously unappreciated role in regulating the innate immune response during intestinal inflammation.