N
Naoya Hosono
Researcher at University of Tokyo
Publications - 58
Citations - 7694
Naoya Hosono is an academic researcher from University of Tokyo. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 38, co-authored 58 publications receiving 7079 citations.
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Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators
Akihiro Fujimoto,Yasushi Totoki,Tetsuo Abe,Keith A. Boroevich,Fumie Hosoda,Ha Hai Nguyen,Masayuki Aoki,Naoya Hosono,Michiaki Kubo,Fuyuki Miya,Yasuhito Arai,Hiroyuki Takahashi,Takuya Shirakihara,Masao Nagasaki,Tetsuo Shibuya,Kaoru Nakano,Kumiko Watanabe-Makino,Hiroko Tanaka,Hiromi Nakamura,Jun Kusuda,Hidenori Ojima,Kazuaki Shimada,Takuji Okusaka,Masaki Ueno,Yoshinobu Shigekawa,Yoshiiku Kawakami,Koji Arihiro,Hideki Ohdan,Kunihito Gotoh,Osamu Ishikawa,Shunichi Ariizumi,Masakazu Yamamoto,Terumasa Yamada,Kazuaki Chayama,Tomoo Kosuge,Hiroki Yamaue,Naoyuki Kamatani,Satoru Miyano,Hitoshi Nakagama,Yusuke Nakamura,Tatsuhiko Tsunoda,Tatsuhiro Shibata,Hidewaki Nakagawa +42 more
TL;DR: The whole-genome sequencing analysis of HCCs identified the influence of etiological background on somatic mutation patterns and subsequent carcinogenesis, as well as recurrent mutations in chromatin regulators in H CCs.
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Genome-wide association study of hematological and biochemical traits in a Japanese population
Yoichiro Kamatani,Koichi Matsuda,Yukinori Okada,Michiaki Kubo,Naoya Hosono,Yataro Daigo,Yusuke Nakamura,Naoyuki Kamatani +7 more
TL;DR: 60 associations for 8 hematological traits and 29 associations for 12 biochemical traits at genome-wide significance levels were identified and compared with those reported in similar GWAS in European populations.
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A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians
Yoichiro Kamatani,Sukanya Wattanapokayakit,Hidenori Ochi,Takahisa Kawaguchi,Atsushi Takahashi,Naoya Hosono,Michiaki Kubo,Tatsuhiko Tsunoda,Naoyuki Kamatani,Hiromitsu Kumada,Aekkachai Puseenam,Thanyachai Sura,Yataro Daigo,Kazuaki Chayama,Wasun Chantratita,Yusuke Nakamura,Koichi Matsuda +16 more
TL;DR: The findings show that genetic variants in the HLA-DP locus are strongly associated with risk of persistent infection with hepatitis B virus.
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Japanese Population Structure, Based on SNP Genotypes from 7003 Individuals Compared to Other Ethnic Groups: Effects on Population-Based Association Studies
Yumi Yamaguchi-Kabata,Kazuyuki Nakazono,Atsushi Takahashi,Susumu Saito,Naoya Hosono,Michiaki Kubo,Yusuke Nakamura,Naoyuki Kamatani +7 more
TL;DR: Japanese population structure was examined by "Eigenanalysis," using the genotypes for 140,387 SNPs in 7003 Japanese individuals, along with 60 European, 60 African, and 90 East-Asian individuals, in the HapMap project, and genetic differentiation was observed.
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Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma
Vinod Kumar,Naoya Kato,Yuji Urabe,Atsushi Takahashi,Ryosuke Muroyama,Naoya Hosono,Motoyuki Otsuka,Ryosuke Tateishi,Masao Omata,Hidewaki Nakagawa,Kazuhiko Koike,Naoyuki Kamatani,Michiaki Kubo,Yusuke Nakamura,Koichi Matsuda +14 more
TL;DR: A previously unidentified locus in the 5′ flanking region of MICA on 6p21.33 was found to be strongly associated with HCV-induced HCC and the risk allele of rs2596542 was associated with lower soluble MICA protein levels in individuals withHCV- induced HCC.