Muheeb Beg

TL;DR: In this article, it was shown that an intact hydrophobic motif domain is required for Glut4-mediated glucose uptake, whereas Glut1-dependent glucose uptake also requires mTORC2 phosphorylation of the HM domain.

TL;DR: It is shown that the closely related fasting/starvation-induced forkhead transcription factors FOXK1 and FOXK2 induce aerobic glycolysis by upregulating the enzymatic machinery required for this, while at the same time suppressing further oxidation of pyruvate in the mitochondria by increasing the activity of pyRuvate dehydrogenase kinases 1 and 4.

TL;DR: The strategy to identify a novel antiadipogenic molecule using CFPMA successfully resulted in identification of rohitukine, which confirmed antiadendipogenic activity and also exhibited in vivo antidyslipidemic activity.

TL;DR: It is demonstrated that both insulin-stimulated glucose uptake and GLUT4 translocation to the plasma membrane are reduced by about half in adipocytes from adipose-specific Rab10 knockout (KO) mice, underscoring the physiological significance of the precise control of insulin-regulated trafficking in adipocyte trafficking.

TL;DR: A coding sequence variant of GIPR, which has been associated with metabolic alterations, has altered post-activation trafficking characterized by enhanced downregulation and prolonged desensitization.