H
Hanyong Sun
Researcher at Shanghai Jiao Tong University
Publications - 14
Citations - 547
Hanyong Sun is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Internal medicine & Medicine. The author has an hindex of 7, co-authored 11 publications receiving 289 citations. Previous affiliations of Hanyong Sun include The Chinese University of Hong Kong.
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Journal ArticleDOI
Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy
Jingying Zhou,Man Liu,Hanyong Sun,Yu Feng,Liangliang Xu,Anthony W.H. Chan,Joanna H.M. Tong,John Wong,Charing C N Chong,Paul B.S. Lai,Hector Kwong-Sang Wang,Shun Wa Tsang,Tyler J. Goodwin,Rihe Liu,Leaf Huang,Zhiwei Chen,Zhiwei Chen,Joseph J.Y. Sung,King Lau Chow,Ka Fai To,Alfred S. L. Cheng +20 more
TL;DR: The results delineate an immunosuppressive mechanism of the hepatoma-intrinsic CCRK signalling and highlight an overexpressed kinase target whose inhibition might empower HCC immunotherapy.
Journal ArticleDOI
Targeting monocyte-intrinsic enhancer reprogramming improves immunotherapy efficacy in hepatocellular carcinoma
Man Liu,Jingying Zhou,Xiaoyu Liu,Yu Feng,Weiqin Yang,Feng Wu,Otto Ka-Wing Cheung,Hanyong Sun,Hanyong Sun,Xuezhen Zeng,Wenshu Tang,Myth T.S. Mok,John Wong,Philip Chun Yeung,Paul B.S. Lai,Zhiwei Chen,Hongchuan Jin,Jie Chen,Stephen L. Chan,Anthony W.H. Chan,Ka Fai To,Joseph J.Y. Sung,Minhu Chen,Alfred S. L. Cheng +23 more
TL;DR: It is shown how non-tumour-intrinsic properties in the desmoplastic microenvironment can be exploited to reinstate immunosurveillance, providing readily translatable combination strategies to empower HCC immunotherapy.
Journal ArticleDOI
Histone Deacetylase HDAC8 Promotes Insulin Resistance and β-Catenin Activation in NAFLD-Associated Hepatocellular Carcinoma.
Yuan Tian,Vincent Wai-Sun Wong,Grace Lai-Hung Wong,Weiqin Yang,Hanyong Sun,Jiayun Shen,Joanna H.M. Tong,Minnie Y.Y. Go,Yue Sun Cheung,Paul B.S. Lai,Mingyan Zhou,Gang Xu,Tim H M Huang,Jun Yu,Ka F. To,Alfred S. L. Cheng,Henry Lik-Yuen Chan +16 more
TL;DR: Overall, the findings show how HDAC8 drives NAFLD-associated hepatocarcinogenesis, offering a novel epigenetic target to prevent or treat HCC in obese patients.
Journal ArticleDOI
An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma.
Hanyong Sun,Hanyong Sun,Weiqin Yang,Yuan Tian,Yuan Tian,Xuezhen Zeng,Jingying Zhou,Myth T.S. Mok,Wenshu Tang,Yu Feng,Liangliang Xu,Anthony W.H. Chan,Joanna H.M. Tong,Yue-Sun Cheung,Paul B.S. Lai,Hector Kwong-Sang Wang,Shun Wa Tsang,King Lau Chow,Mengying Hu,Rihe Liu,Leaf Huang,Bing Yang,Pengyuan Yang,Ka Fai To,Joseph J.Y. Sung,Grace Lai-Hung Wong,Vincent Wai-Sun Wong,Alfred S. L. Cheng +27 more
TL;DR: The authors find a potential mechanistic explanation by showing that, in mice, obesity-induced STAT3 cooperates with the androgen receptor to activate the mTORC pathway through up regulation of CCRK, resulting in hepatic steatosis worsening and HCC development via metabolic and immune reprogramming.
Journal ArticleDOI
A selective HDAC8 inhibitor potentiates antitumor immunity and efficacy of immune checkpoint blockade in hepatocellular carcinoma.
Weiqin Yang,Yu Feng,Jingying Zhou,Otto Ka-Wing Cheung,Jianquan Cao,Jing Wang,Wenshu Tang,Yalin Tu,Liangliang Xu,Feng Wu,Zhiwu Tan,Hanyong Sun,Yuan Tian,John Wong,Paul B.S. Lai,Stephen L. Chan,Anthony W.H. Chan,Patrick Boon-Ooi Tan,Zhiwei Chen,Joseph J.Y. Sung,Joseph J.Y. Sung,Joseph J.Y. Sung,Kevin Y. Yip,Ka Fai To,Alfred S. L. Cheng +24 more
TL;DR: In this article, the authors showed that down-regulation of histone deacetylase 8 (HDAC8) increased global and enhancer acetylation of H3K27 to reactivate production of T cell-trafficking chemokines by HCC cells.