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Nadine Herr
Researcher at University of Freiburg
Publications - 11
Citations - 765
Nadine Herr is an academic researcher from University of Freiburg. The author has contributed to research in topics: Inflammation & Serotonin. The author has an hindex of 6, co-authored 11 publications receiving 544 citations.
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Journal ArticleDOI
The Effects of Serotonin in Immune Cells
TL;DR: Serotonin can also suppress the release of tumor necrosis factor-α and interleukin-1β by activating serotonin receptors, and neutrophil recruitment and T-cell activation can both be mediated by serotonin.
Journal ArticleDOI
Platelet serotonin promotes the recruitment of neutrophils to sites of acute inflammation in mice
Daniel Duerschmied,Georgette L. Suidan,Georgette L. Suidan,Melanie Demers,Melanie Demers,Nadine Herr,Carla Carbo,Carla Carbo,Alexander Brill,Alexander Brill,Stephen M. Cifuni,Maximilian Mauler,Sanja Cicko,Michael Bader,Marco Idzko,Christoph Bode,Denisa D. Wagner,Denisa D. Wagner +17 more
TL;DR: Platelet serotonin promotes the recruitment of neutrophils in acute inflammation, supporting an important role for platelet serotonin in innate immunity.
Journal ArticleDOI
Binding of CD40L to Mac-1's I-domain involves the EQLKKSKTL motif and mediates leukocyte recruitment and atherosclerosis--but does not affect immunity and thrombosis in mice.
Dennis Wolf,Jan David Hohmann,Ansgar Wiedemann,Kamila Bledzka,Hermann Blankenbach,Timoteo Marchini,Katharina Gutte,Katharina Zeschky,Nicole Bassler,Natalie Hoppe,Alexandra Ortiz Rodriguez,Nadine Herr,Ingo Hilgendorf,Peter Stachon,Florian Willecke,Daniel Duerschmied,Constantin von zur Mühlen,Dmitry A. Soloviev,Li Zhang,Christoph Bode,Edward F. Plow,Peter Libby,Karlheinz Peter,Andreas Zirlik +23 more
TL;DR: The novel finding that CD40L binds to the EQLKKSKTL motif on Mac-1 mediating leukocyte recruitment and atherogenesis is presented, potentially avoiding the unwanted immunologic and thrombotic effects of global inhibition ofCD40L.
Journal ArticleDOI
Platelet Serotonin Aggravates Myocardial Ischemia/Reperfusion Injury via Neutrophil Degranulation
Maximilian Mauler,Nadine Herr,Claudia Schoenichen,Thilo Witsch,Timoteo Marchini,Carmen Härdtner,Christoph Koentges,Korbinian Kienle,Korbinian Kienle,Véronique Ollivier,Véronique Ollivier,Maximilian Schell,Ludwig Dorner,Christopher Wippel,Daniela Stallmann,Claus Normann,Claus Normann,Heiko Bugger,Paul Walther,Dennis Wolf,Dennis Wolf,Ingo Ahrens,Tim Lämmermann,Benoît Ho-Tin-Noé,Benoît Ho-Tin-Noé,Klaus Ley,Christoph Bode,Ingo Hilgendorf,Daniel Duerschmied +28 more
TL;DR: Serotonin is identified as a potent therapeutic target in neutrophil-dependent thromboinflammation during myocardial reperfusion injury and patients with depression using serotonin reuptake inhibition are presented with suppressed levels of CD11b surface expression on neutrophils and lower myeloperoxidase levels in blood.
Journal ArticleDOI
Acute Fluoxetine Treatment Induces Slow Rolling of Leukocytes on Endothelium in Mice
Nadine Herr,Maximilian Mauler,Thilo Witsch,Daniela Stallmann,Stefanie Schmitt,Julius Mezger,Christoph Bode,Daniel Duerschmied +7 more
TL;DR: Acute fluoxetine treatment increased plasma serotonin concentrations and promoted leukocyte-endothelial interactions in-vivo, suggesting that serotonin is a promoter of acute inflammation.