D
David W. Hoyt
Researcher at Environmental Molecular Sciences Laboratory
Publications - 112
Citations - 5025
David W. Hoyt is an academic researcher from Environmental Molecular Sciences Laboratory. The author has contributed to research in topics: Supercritical fluid & Magic angle spinning. The author has an hindex of 33, co-authored 99 publications receiving 3776 citations. Previous affiliations of David W. Hoyt include Battelle Memorial Institute & Ohio State University.
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Journal ArticleDOI
Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice
Gil Sharon,Nikki Jamie Cruz,Dae Wook Kang,Michael J. Gandal,B. D. Wang,Young-Mo Kim,Erika M. Zink,Cameron P. Casey,Bryn C. Taylor,Christianne J. Lane,Lisa M. Bramer,Nancy G. Isern,David W. Hoyt,Cecilia Noecker,Michael J. Sweredoski,Annie Moradian,Elhanan Borenstein,Janet K. Jansson,Rob Knight,Thomas O. Metz,Carlos Lois,Daniel H. Geschwind,Rosa Krajmalnik-Brown,Sarkis K. Mazmanian +23 more
TL;DR: It is proposed that the gut microbiota regulates behaviors in mice via production of neuroactive metabolites, suggesting that gut-brain connections contribute to the pathophysiology of ASD.
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Structure of a BRCA1-BARD1 heterodimeric RING-RING complex.
TL;DR: The BRCA1–BARD1 structure provides a model for its ubiquitin ligase activity, illustrates how the BRCa1 RING domain can be involved in associations with multiple protein partners and provides a framework for understanding cancer-causing mutations at the molecular level.
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A UbcH5/Ubiquitin Noncovalent Complex Is Required for Processive BRCA1-Directed Ubiquitination
TL;DR: Self-assembly has profound consequences for the processive formation of polyubiquitin (poly-Ub) chains in ubiquitination reactions directed by the breast and ovarian cancer tumor susceptibility protein BRCA1.
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Differences in fecal microbial metabolites and microbiota of children with autism spectrum disorders.
Dae Wook Kang,Zehra Esra Ilhan,Nancy G. Isern,David W. Hoyt,Daniel P. Howsmon,Michael Shaffer,Catherine A. Lozupone,Juergen Hahn,James B. Adams,Rosa Krajmalnik-Brown +9 more
TL;DR: The data in this study support that children with ASD have altered metabolite profiles in feces when compared with neurotypical children and warrant further investigation of metabolites in larger cohorts.
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Microbial metabolisms in a 2.5-km-deep ecosystem created by hydraulic fracturing in shales
Rebecca A. Daly,Mikayla A. Borton,Michael J. Wilkins,David W. Hoyt,Duncan J. Kountz,Richard A. Wolfe,Susan A. Welch,Daniel N. Marcus,Ryan V. Trexler,Jean D. MacRae,Joseph A. Krzycki,David R. Cole,Paula J. Mouser,Kelly C. Wrighton +13 more
TL;DR: Reconstruction of 31 unique genomes coupled to metabolite data from the Marcellus and Utica shales revealed that many of the persisting organisms play roles in methylamine cycling, ultimately supporting methanogenesis in the deep biosphere.