Natasha S. Hamblet

TL;DR: The bicoid-related transcription factor Pitx2 is rapidly induced by the Wnt/Dvl/beta-catenin pathway and is required for effective cell-type-specific proliferation by directly activating specific growth-regulating genes.

TL;DR: Dvl2 is essential for normal cardiac morphogenesis, somite segmentation and neural tube closure, and there is functional redundancy between Dvl1 and Dvl2 in some phenotypes.

TL;DR: A high degree of conservation between Dvl function in mammalian convergent extension and the PCP pathway in fly is demonstrated, and in the neuroepithelium of neurulating embryos, Dvl2 shows DEP domain-dependent membrane localization, a pre-requisite for its involvement in convergent extensions.

TL;DR: It is demonstrated that Dvl3 is required for cardiac outflow tract development and its importance in the PCP pathway during neurulation and cochlea development and several developmental processes in which the three Dvls are functionally redundant are established.