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Neeltje van Doremalen
Researcher at National Institutes of Health
Publications - 88
Citations - 18277
Neeltje van Doremalen is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Middle East respiratory syndrome coronavirus & Medicine. The author has an hindex of 33, co-authored 73 publications receiving 13674 citations. Previous affiliations of Neeltje van Doremalen include Rocky Mountain Laboratories.
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Journal ArticleDOI
ChAdOx1-vectored Lassa fever vaccine elicits a robust cellular and humoral immune response and protects guinea pigs against lethal Lassa virus challenge
Robert J. Fischer,Jyothi N. Purushotham,Jyothi N. Purushotham,Neeltje van Doremalen,Sarah Sebastian,Kimberly Meade-White,Kathleen Cordova,Michael Letko,Michael Letko,M. Jeremiah Matson,M. Jeremiah Matson,Friederike Feldmann,Elaine Haddock,Rachel A. LaCasse,Greg Saturday,Teresa Lambe,Sarah C. Gilbert,Vincent J. Munster +17 more
TL;DR: ChAdOx1-Lassa-GPC is a chimpanzee adenovirus-vectored vaccine encoding the Josiah strain LASV glycoprotein precursor (GPC) gene as mentioned in this paper.
Journal ArticleDOI
Ebola Laboratory Response at the Eternal Love Winning Africa Campus, Monrovia, Liberia, 2014-2015.
Emmie de Wit,Kyle Rosenke,Robert J. Fischer,Andrea Marzi,Joseph Prescott,Trenton Bushmaker,Neeltje van Doremalen,Shannon L. Emery,Darryl Falzarano,Friederike Feldmann,Allison Groseth,Thomas Hoenen,Bonventure Juma,Kristin L. McNally,Melvin Ochieng,Victor Omballa,Clayton Onyango,Collins Owuor,Thomas Rowe,David Safronetz,Joshua S. Self,Brandi N. Williamson,Galina E. Zemtsova,Allen Grolla,Gary P. Kobinger,Mark A. Rayfield,Ute Ströher,James E. Strong,Sonja M. Best,Hideki Ebihara,Kathryn C. Zoon,Stuart T. Nichol,Tolbert Nyenswah,Fatorma K. Bolay,Moses Massaquoi,Heinz Feldmann,Barry S. Fields +36 more
TL;DR: West Africa experienced the first epidemic of Ebola virus infection, with by far the greatest number of cases in Guinea, Sierra Leone, and Liberia, and the deployment of multiple Ebola treatment units and mobile/field diagnostic laboratories is described and discussed.
Journal ArticleDOI
Recovery from Acute SARS-CoV-2 Infection and Development of Anamnestic Immune Responses in T Cell-Depleted Rhesus Macaques.
Kim J. Hasenkrug,Friederike Feldmann,Lara Myers,Mario L. Santiago,Kejun Guo,Bradley S. Barrett,Kaylee L Mickens,Aaron B. Carmody,Atsushi Okumura,Deepashri Rao,Madison M Collins,Ronald J. Messer,Jamie Lovaglio,Carl Shaia,Rebecca Rosenke,Neeltje van Doremalen,Chad S Clancy,Greg Saturday,Patrick W. Hanley,Brian J. Smith,Kimberly Meade-White,W. Lesley Shupert,David W Hawman,Heinz Feldmann +23 more
TL;DR: In this article, the authors investigated the specific role of T cells in recovery from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, and they studied rhesus macaques that were depleted of either CD4+, CD8+, or both T cell subsets prior to infection.
Journal ArticleDOI
The B.1.427/1.429 (epsilon) SARS-CoV-2 variants are more virulent than ancestral B.1 (614G) in Syrian hamsters
Timothy D. Carroll,Douglas M. Fox,Neeltje van Doremalen,Erin E. Ball,Mary Kate Morris,Alicia Sotomayor-Gonzalez,Venice Servellita,Arjun Rustagi,Claude Kwe Yinda,Linda Fritts,Julia R Port,Zhong-Min Ma,Myndi G. Holbrook,Jonathan E Schulz,Catherine A. Blish,Carl L. Hanson,Charles Y. Chiu,Vincent J. Munster,Sarah A. Stanley,Christopher J. Miller +19 more
TL;DR: The virulence, transmissibility, and susceptibility to pre-existing immunity for B 1.1.427 and B 1-1.429 in the Syrian hamster model is examined to demonstrate enhanced virulence and high relative oropharyngeal replication of the epsilon variant in Syrian hamsters compared to an ancestral B.1 (614G) and WA-1 variant.
Posted ContentDOI
SARS-CoV-2 disease severity and transmission efficiency is increased for airborne but not fomite exposure in Syrian hamsters
Julia R Port,Claude Kwe Yinda,Irene Offei Owusu,Myndi G. Holbrook,Robert S. Fischer,Trenton Bushmaker,Trenton Bushmaker,Victoria A. Avanzato,Jonathan E Schulz,Neeltje van Doremalen,Chad S Clancy,Vincent J. Munster +11 more
TL;DR: In this paper, the authors show that Syrian hamsters are susceptible to SARS-CoV-2 infection through intranasal, aerosol and fomite exposure.