Eduardo J. Contijoch

TL;DR: The timing ofIFN-induced innate responses in acute SIV infection profoundly affects overall disease course and outweighs the detrimental consequences of increased immune activation, yet the clinical consequences of manipulation of IFN signalling are difficult to predict in vivo and therapeutic interventions in human studies should be approached with caution.

TL;DR: An impact on intestinal Th17 and ROR&ggr;t+ regulatory T cell compartments emerges as a unifying feature of IBD microbiotas, suggesting a general mechanism for microbial contribution to IBD pathogenesis.

TL;DR: In this paper, the effects of different dietary components and the gut microbiota on mice with and without DSS-induced colitis were analyzed, and the authors found complex mixtures of nutrients affect intestinal permeability, gut microbial density, and development of intestinal inflammation.

TL;DR: Understanding the interplay between microbiota and disease in terms of microbiota density, host carrying capacity, and microbiota fitness provide new insights into microbiome structure and microbiome targeted therapeutics.

TL;DR: Assessment of the IgA-inducing capacity of a diverse set of human gut microbial strains by monocolonizing mice with each strain identified Bacteroides ovatus as the species that best induced gut IgA production.