N
Nicola L. Harris
Researcher at Monash University
Publications - 121
Citations - 10360
Nicola L. Harris is an academic researcher from Monash University. The author has contributed to research in topics: Immune system & Heligmosomoides polygyrus. The author has an hindex of 40, co-authored 110 publications receiving 8780 citations. Previous affiliations of Nicola L. Harris include University of Lausanne & University of Otago.
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Microbiota Analysis Using an Illumina MiSeq Platform to Sequence 16S rRNA Genes
TL;DR: By extracting the entire DNA content of a microbiota sample and performing a targeted high‐throughput sequencing of the 16S rRNA gene, a phylogenetic marker for prokaryotes, prediction of the composition of the entire bacterial community is made possible.
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An anti-inflammatory eicosanoid switch mediates the suppression of type-2 inflammation by helminth larval products
Marta de los Reyes Jiménez,Antonie Lechner,Francesca Alessandrini,Sina Bohnacker,Sonja Schindela,Aurélien Trompette,Pascal Haimerl,Dominique Thomas,Fiona Henkel,André Mourão,Arie Geerlof,Clarissa Prazeres da Costa,Adam Chaker,Bernhard Brüne,Rolf M. Nüsing,Per-Johan Jakobsson,Wolfgang Andreas Nockher,Matthias J. Feige,Martin Haslbeck,Caspar Ohnmacht,Benjamin J. Marsland,David Voehringer,Nicola L. Harris,Carsten B. Schmidt-Weber,Julia Esser-von Bieren +24 more
TL;DR: Larval products of the helminth Heligmosomoides polygyrus bakeri (HpbE), known to modulate type-2 responses, trigger a broad anti-inflammatory eicosanoid shift by suppressing the 5-lipoxygenase pathway, but inducing the cyclooxygenases (COX) pathway.
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Enteric neuroimmune interactions coordinate intestinal responses in health and disease.
TL;DR: In this paper, the authors discuss how the enteric nervous system (ENS) can regulate and be regulated by immune responses and how such interactions control whole tissue physiology, and address the requirements for the proper regeneration of the ENS and restoration of GI function following the resolution of infection.
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Antibody-Mediated Trapping of Helminth Larvae Requires CD11b and Fcγ Receptor I
Julia Esser-von Bieren,Beatrice Volpe,Manuel Kulagin,Duncan B. Sutherland,Romain Guiet,Arne Seitz,Benjamin J. Marsland,J. Sjef Verbeek,Nicola L. Harris +8 more
TL;DR: A novel role is revealed for IgG2a/c-FcγRI–driven MΦ activation in the efficient trapping of tissue-migrating helminth larvae and thus provide important mechanistic insights vital for anti-helminth vaccine development.
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Microbial metabolism of L-tyrosine protects against allergic airway inflammation.
Tomasz P. Wypych,Céline Pattaroni,Olaf Perdijk,Carmen Yap,Aurélien Trompette,Dovile Anderson,Darren J. Creek,Nicola L. Harris,Benjamin J. Marsland +8 more
TL;DR: In this paper, a mouse model of restricted antibody repertoire was used to identify a role for antibody-microbe interactions in shaping a community of bacteria with an enhanced capacity to metabolize L-tyrosine.