N
Nicola L. Harris
Researcher at Monash University
Publications - 121
Citations - 10360
Nicola L. Harris is an academic researcher from Monash University. The author has contributed to research in topics: Immune system & Heligmosomoides polygyrus. The author has an hindex of 40, co-authored 110 publications receiving 8780 citations. Previous affiliations of Nicola L. Harris include University of Lausanne & University of Otago.
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Journal ArticleDOI
IL-1β suppresses innate IL-25 and IL-33 production and maintains helminth chronicity.
Mario M. Zaiss,Kendle M. Maslowski,Ilaria Mosconi,Nadine Guenat,Benjamin J. Marsland,Nicola L. Harris +5 more
TL;DR: It is found that the natural murine helminth, Heligmosomoides polygyrus bakeri (Hp) elicits the secretion of IL-1β in vivo and in vitro and that this cytokine is critical for shaping a mucosal environment suited to helminths chronicity.
Journal ArticleDOI
Natural IgE Production in the Absence of MHC Class II Cognate Help
Kathy D. McCoy,Nicola L. Harris,Philipp Diener,Sarah Hatak,Bernhard Odermatt,Lars Hangartner,Beatrice M. Senn,Benjamin J. Marsland,Markus B. Geuking,Hans Hengartner,Andrew J. Macpherson,Rolf M. Zinkernagel +11 more
TL;DR: It is demonstrated that spontaneously produced IgE in T cell-deficient and germ-free wild-type (wt) mice is composed of natural specificities and induced by a mechanism independent of MHC class II (MHC II) cognate help.
Journal ArticleDOI
Intestinal bacteria condition dendritic cells to promote IgA production.
Joanna Massacand,Patrick Kaiser,Bettina Ernst,Aubry Tardivel,Kurt Bürki,Pascal Schneider,Nicola L. Harris +6 more
TL;DR: Exposure to pathogen-associated molecular patterns present on intestinal commensal bacteria condition DC to express a unique molecular footprint that in turn allows them to promote IgA production is indicated.
Journal ArticleDOI
Differential requirement for CD80 and CD80/CD86-dependent costimulation in the lung immune response to an influenza virus infection
TL;DR: In vivo treatment with CTLA4-Ig to block the interaction of CD28 with CD80 and CD86 reduced virus-specific cytotoxicity and IFN-γ production by bronchoalveolar lavage fluid CD8+ T lymphocytes in vitro and indicated that CD28-dependent costimulation is important in the antiviral immune response to an influenza virus infection.
Journal ArticleDOI
Antibodies Trap Tissue Migrating Helminth Larvae and Prevent Tissue Damage by Driving IL-4Rα-Independent Alternative Differentiation of Macrophages
Julia Esser-von Bieren,Ilaria Mosconi,Romain Guiet,Alessandra Piersgilli,Beatrice Volpe,Fei-Fei Chen,William C. Gause,Arne Seitz,J. Sjef Verbeek,Nicola L. Harris +9 more
TL;DR: It is demonstrated that helminth-specific antibodies induce the rapid trapping of tissue migrating helminths larvae and prevent tissue necrosis following challenge infection with the natural murine parasite Heligmosomoides polygyrus bakeri (Hp).