N
Nicola L. Harris
Researcher at Monash University
Publications - 121
Citations - 10360
Nicola L. Harris is an academic researcher from Monash University. The author has contributed to research in topics: Immune system & Heligmosomoides polygyrus. The author has an hindex of 40, co-authored 110 publications receiving 8780 citations. Previous affiliations of Nicola L. Harris include University of Lausanne & University of Otago.
Papers
More filters
Journal ArticleDOI
Inverse correlation between IL-7 receptor expression and CD8 T cell exhaustion during persistent antigen stimulation.
Karl S. Lang,Mike Recher,Alexander A. Navarini,Nicola L. Harris,Max Löhning,Tobias Junt,Hans Christian Probst,Hans Hengartner,Rolf M. Zinkernagel +8 more
TL;DR: It is demonstrated here that persistent antigen suppressed IL‐7Rα expression and this correlated with T cell exhaustion and reduced expression of the anti‐apoptotic molecule B cell leukemia/lymphoma 2 (Bcl‐2).
Journal ArticleDOI
The role of B7 costimulation in T-cell immunity
Nicola L. Harris,Franca Ronchese +1 more
TL;DR: The present review outlines the current understanding of the physiological role of B7 costimulatory signals in regulating CD4+ T cell responses and identifies two major signalling pathways responsible for delivery.
Journal ArticleDOI
Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling
Karl S. Lang,Panco Georgiev,Mike Recher,Alexander A. Navarini,Andreas Bergthaler,Mathias Heikenwalder,Nicola L. Harris,Tobias Junt,Tobias Junt,Bernhard Odermatt,Pierre-Alain Clavien,Hanspeter Pircher,Shizuo Akira,Hans Hengartner,Rolf M. Zinkernagel +14 more
TL;DR: It is demonstrated that highly activated liver-specific effector CD8+ T cells alone were not sufficient to trigger immune destruction of the liver in mice, and only additional innate immune signals orchestrated by TLR3 provoked liver damage.
Journal ArticleDOI
Helminth products bypass the need for TSLP in Th2 immune responses by directly modulating dendritic cell function.
Joanna Massacand,Rebecca Stettler,Reto Meier,Neil E. Humphreys,Richard K. Grencis,Benjamin J. Marsland,Nicola L. Harris,Nicola L. Harris +7 more
TL;DR: It is reported that the interaction of TSLP with its receptor (TSLPR) has no functional impact on the development of protective Th2 immune responses after infection with 2 helminth pathogens, Heligmosomoides polygyrus and Nippostrongylus brasiliensis.
Journal ArticleDOI
Polyclonal and Specific Antibodies Mediate Protective Immunity against Enteric Helminth Infection
Kathy D. McCoy,Maaike Stoel,Rebecca Stettler,Patrick Merky,Katja Fink,Beatrice M. Senn,Corinne Schaer,Joanna Massacand,Bernhard Odermatt,Hans C. Oettgen,Rolf M. Zinkernagel,Nicolaas A. Bos,Hans Hengartner,Andrew J. Macpherson,Nicola L. Harris +14 more
TL;DR: It is proposed that parasite-induced polyclonal antibodies play a dual role, whereby the parasite is allowed to establish chronicity, while parasite load and spread are limited, likely reflecting the long coevolution of helminth parasites with their hosts.