Nicola L. Harris

TL;DR: Chronic infection with the murine helminth Heligmosomoides polygyrus bakeri altered the intestinal habitat, allowing increased short chain fatty acid (SCFA) production and a similar alteration in the metabolic potential of intestinal bacterial communities was observed with diverse parasitic and host species, suggesting that this represents an evolutionary conserved mechanism of host-microbe-helminth interactions.

TL;DR: Targeted insertion of Cre-recombinase into the mast cell carboxypeptidase A3 locus deleted mast cells in connective and mucosal tissues by a genotoxic Trp53-dependent mechanism.

TL;DR: Serotonin treatment of infected mice delayed entry of activated CD8+ T cells into the liver, delayed virus control and aggravated immunopathological hepatitis, suggesting vasoactive serotonin supports virus persistence in the liver and aggravates virus-induced immunopathology.

TL;DR: It is shown in mice that different Ab isotypes work in distinct ways to protect the neonatal mucosal surface, and secretory IgA acts to limit penetration of commensal intestinal bacteria through the Neonatal intestinal epithelium.

TL;DR: Activated T cells can undergo clonal expansion in the lymph node, but are recruited and retained as nondividing cells in nonlymphoid tissues, revealing simple key mechanisms for both inducing and limiting T cell immunity.