N
Nicola L. Harris
Researcher at Monash University
Publications - 121
Citations - 10360
Nicola L. Harris is an academic researcher from Monash University. The author has contributed to research in topics: Immune system & Heligmosomoides polygyrus. The author has an hindex of 40, co-authored 110 publications receiving 8780 citations. Previous affiliations of Nicola L. Harris include University of Lausanne & University of Otago.
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Journal ArticleDOI
Deliberate removal of T cell help improves virus-neutralizing antibody production
Mike Recher,Karl S. Lang,Lukas Hunziker,Lukas Hunziker,Stefan Freigang,Bruno Eschli,Nicola L. Harris,Alexander A. Navarini,Beatrice M. Senn,Katja Fink,Marius Lötscher,Lars Hangartner,Raphaël M. Zellweger,Martin Hersberger,Alexandre Theocharides,Hans Hengartner,Rolf M. Zinkernagel +16 more
TL;DR: Evidence is provided that, paradoxically, because of polyclonal B cell activation, virus-specific T cell help impairs the induction of neutralizing antibody responses.
Journal ArticleDOI
Nippostrongylus brasiliensis infection leads to the development of emphysema associated with the induction of alternatively activated macrophages
TL;DR: It is shown here that infection with the hookworm Nippostrongylus brasiliensis results in deterioration in lung function, destruction of alveoli and long‐term airways hyperresponsiveness, consistent with COPD and emphysema.
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Enteric helminth-induced type I interferon signaling protects against pulmonary virus infection through interaction with the microbiota
Amanda J. McFarlane,Henry J. McSorley,Donald J. Davidson,Paul M. Fitch,Claire Errington,Karen J. Mackenzie,Eva S. Gollwitzer,Chris J. C. Johnston,Andrew S. MacDonald,Michael R. Edwards,Nicola L. Harris,Benjamin J. Marsland,Rick M. Maizels,Jürgen Schwarze +13 more
TL;DR: It is demonstrated that a strictly enteric helminth infection can have remote protective antiviral effects in the lung through induction of a microbiota‐dependent type I interferon response.
Journal ArticleDOI
Tissue macrophages suppress viral replication and prevent severe immunopathology in an interferon‐I‐dependent manner in mice
Philipp A. Lang,Philipp A. Lang,Mike Recher,Nadine Honke,Stefanie Scheu,Stephanie Borkens,Nicole Gailus,Caroline Krings,Andreas Meryk,Andreas Kulawik,Luisa Cervantes-Barragan,Nico van Rooijen,Ulrich Kalinke,Burkhard Ludewig,Hans Hengartner,Nicola L. Harris,Dieter Häussinger,Pamela S. Ohashi,Rolf M. Zinkernagel,Karl S. Lang,Karl S. Lang +20 more
TL;DR: Tissue‐resident macrophages play a crucial role in early viral capture and represent the major liver cell type exhibiting responsiveness to IFN‐I and providing control of viral replication.
Journal ArticleDOI
Concerted Activity of IgG1 Antibodies and IL-4/IL-25-Dependent Effector Cells Trap Helminth Larvae in the Tissues following Vaccination with Defined Secreted Antigens, Providing Sterile Immunity to Challenge Infection
James P. Hewitson,Kara J. Filbey,Julia Esser-von Bieren,Mali Camberis,Christian Schwartz,Janice Murray,Lisa A. Reynolds,Natalie F. Blair,Elaine Robertson,Yvonne Harcus,Louis Boon,Stanley Ching-Cheng Huang,Lihua Yang,Yizheng Tu,Mark J. Miller,David Voehringer,Graham Le Gros,Nicola L. Harris,Rick M. Maizels +18 more
TL;DR: Data indicate that vaccine-induced immunity to intestinal helminths involves IgG1 antibodies directed against secreted proteins acting in concert with IL-25-dependent Type 2 myeloid effector populations, and a suite of previously uncharacterised heat-labile vaccine antigens with homologs in human and veterinary parasites that together promote full immunity.